Trait
Large hands
Summary
- Also called
- large hand, Disproportionately large hands
- Body system
- Abnormality of limbs
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test33 genes linked to Large hands
Changes in these genes cause rare conditions in which Large hands is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EEDembryonic ectoderm development | Always | In 1 condition |
| GNPNAT1glucosamine-phosphate N-acetyltransferase 1 | Always | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Always | In 1 condition |
| KDM5Clysine demethylase 5C | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 3 conditions |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Always | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 2 conditions |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 1 condition |
| MEN1menin 1 | Very often (80–99%) | In 1 condition |
| PHF8PHD finger protein 8 | Very often (80–99%) | In 2 conditions |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Very often (80–99%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Very often (80–99%) | In 2 conditions |
| RPS6KA3ribosomal protein S6 kinase A3 | Very often (80–99%) | In 2 conditions |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Often (30–79%) | In 2 conditions |
| NF1neurofibromin 1 | Often (30–79%) | In 2 conditions |
| PEX1peroxisomal biogenesis factor 1 | Often (30–79%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Often (30–79%) | In 2 conditions |
| APC2APC regulator of Wnt signaling pathway 2 | Sometimes (5–29%) | In 1 condition |
| ARCN1archain 1 coat protein complex I subunit delta | Sometimes (5–29%) | In 1 condition |
| FIBPFGF1 intracellular binding protein | Sometimes (5–29%) | In 2 conditions |
| INSRinsulin receptor | Sometimes (5–29%) | In 2 conditions |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2 | Not recorded | In 1 condition |
| ASNSasparagine synthetase (glutamine-hydrolyzing) | Not recorded | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Not recorded | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Not recorded | In 1 condition |
| PACS1phosphofurin acidic cluster sorting protein 1 | Not recorded | In 1 condition |
| POLR3ARNA polymerase III subunit A | Not recorded | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Not recorded | In 1 condition |
| SDHCsuccinate dehydrogenase complex subunit C | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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