Trait
Thickened skin
Laminar thickening of skin.
Summary
- Also called
- Diffusely thickened skin, Thick skin, Pachydermia
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Thickened skin, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test73 genes linked to Thickened skin
Changes in these genes cause rare conditions in which Thickened skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AK2adenylate kinase 2 | Always | In 1 condition |
| LMNAlamin A/C | Always | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Always | In 3 conditions |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 2 conditions |
| ARSBarylsulfatase B | Very often (80–99%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Very often (80–99%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Very often (80–99%) | In 1 condition |
| ECM1extracellular matrix protein 1 | Very often (80–99%) | In 2 conditions |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| FBN1fibrillin 1 | Very often (80–99%) | In 6 conditions |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Very often (80–99%) | In 3 conditions |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Very often (80–99%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Very often (80–99%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Very often (80–99%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Very often (80–99%) | In 1 condition |
| PERPp53 apoptosis effector related to PMP22 | Very often (80–99%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Very often (80–99%) | In 1 condition |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 2 conditions |
| TGM1transglutaminase 1 | Very often (80–99%) | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Very often (80–99%) | In 1 condition |
| TUBBtubulin beta class I | Very often (80–99%) | In 1 condition |
| XPAXPA, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| ADAadenosine deaminase | Often (30–79%) | In 1 condition |
| ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10 | Often (30–79%) | In 2 conditions |
| ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17 | Often (30–79%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Often (30–79%) | In 2 conditions |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Often (30–79%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Often (30–79%) | In 2 conditions |
| GATA1GATA binding protein 1 | Often (30–79%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Often (30–79%) | In 1 condition |
Show 33 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| IL7Rinterleukin 7 receptor | Often (30–79%) | In 1 condition |
| LARP7La ribonucleoprotein 7, transcriptional regulator | Often (30–79%) | In 1 condition |
| LTBP2latent transforming growth factor beta binding protein 2 | Often (30–79%) | In 1 condition |
| LTBP3latent transforming growth factor beta binding protein 3 | Often (30–79%) | In 2 conditions |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Often (30–79%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Often (30–79%) | In 1 condition |
| RAG1recombination activating 1 | Often (30–79%) | In 2 conditions |
| RAG2recombination activating 2 | Often (30–79%) | In 2 conditions |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 1 condition |
| SLC45A2solute carrier family 45 member 2 | Often (30–79%) | In 1 condition |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Often (30–79%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Often (30–79%) | In 2 conditions |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Often (30–79%) | In 2 conditions |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| GJB6gap junction protein beta 6 | Sometimes (5–29%) | In 1 condition |
| GLB1galactosidase beta 1 | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| NOTCH2notch receptor 2 | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Sometimes (5–29%) | In 1 condition |
| PPOXprotoporphyrinogen oxidase | Sometimes (5–29%) | In 1 condition |
| TTC7Atetratricopeptide repeat domain 7A | Sometimes (5–29%) | In 1 condition |
| TYRtyrosinase | Sometimes (5–29%) | In 2 conditions |
| URODuroporphyrinogen decarboxylase | Sometimes (5–29%) | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| MMP2matrix metallopeptidase 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks