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Trait
Body fails to respond to insulin
Clinical name: Insulin resistance
Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels.
Summary
- Body system
- Laboratory abnormality
Body fails to respond to insulinHP:0000855
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Read the genes linked to Body fails to respond to insulin, and the rest of your genome, with one test.
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Get my Genome Test89 genes linked to Body fails to respond to insulin
Changes in these genes cause rare conditions in which Body fails to respond to insulin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AKT2AKT serine/threonine kinase 2 | Always | In 2 conditions |
| ARL6ARF like GTPase 6 | Always | In 2 conditions |
| BBS1Bardet-Biedl syndrome 1 | Always | In 2 conditions |
| CCDC28Bcoiled-coil domain containing 28B | Always | In 1 condition |
| INSRinsulin receptor | Always | In 4 conditions |
| LIPElipase E, hormone sensitive type | Always | In 2 conditions |
| LMNAlamin A/C | Always | In 6 conditions |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Always | In 1 condition |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Always | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Always | In 2 conditions |
| PLIN1perilipin 1 | Always | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Always | In 1 condition |
| PPARGperoxisome proliferator activated receptor gamma | Always | In 3 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Very often (80–99%) | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Very often (80–99%) | In 1 condition |
| IGF1insulin like growth factor 1 | Very often (80–99%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| BLMBLM RecQ like helicase | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 2 conditions |
| CYP19A1cytochrome P450 family 19 subfamily A member 1 | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Often (30–79%) | In 1 condition |
| HSD11B1hydroxysteroid 11-beta dehydrogenase 1 | Often (30–79%) | In 1 condition |
| LEMD2LEM domain nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| MFN2mitofusin 2 | Often (30–79%) | In 1 condition |
| WRNWRN RecQ like helicase | Often (30–79%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Often (30–79%) | In 2 conditions |
| ADCY3adenylate cyclase 3 | Sometimes (5–29%) | In 1 condition |
| BBIP1BBSome interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| BBS10Bardet-Biedl syndrome 10 | Sometimes (5–29%) | In 1 condition |
| BBS12Bardet-Biedl syndrome 12 | Sometimes (5–29%) | In 1 condition |
| BBS2Bardet-Biedl syndrome 2 | Sometimes (5–29%) | In 1 condition |
| BBS4Bardet-Biedl syndrome 4 | Sometimes (5–29%) | In 1 condition |
| BBS5Bardet-Biedl syndrome 5 | Sometimes (5–29%) | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Sometimes (5–29%) | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| CEP19centrosomal protein 19 | Sometimes (5–29%) | In 2 conditions |
| CEP290centrosomal protein 290 | Sometimes (5–29%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Sometimes (5–29%) | In 1 condition |
Show 49 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CLCNKBchloride voltage-gated channel Kb | Sometimes (5–29%) | In 1 condition |
| GRB10growth factor receptor bound protein 10 | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| IFT27intraflagellar transport 27 | Sometimes (5–29%) | In 1 condition |
| IFT74intraflagellar transport 74 | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| LMNB2lamin B2 | Sometimes (5–29%) | In 1 condition |
| LZTFL1leucine zipper transcription factor like 1 | Sometimes (5–29%) | In 1 condition |
| MKKSMKKS centrosomal shuttling protein | Sometimes (5–29%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| NPHP1nephrocystin 1 | Sometimes (5–29%) | In 1 condition |
| PHLDB1pleckstrin homology like domain family B member 1 | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 1 condition |
| SCAPERS-phase cyclin A associated protein in the ER | Sometimes (5–29%) | In 1 condition |
| SCLT1sodium channel and clathrin linker 1 | Sometimes (5–29%) | In 1 condition |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Sometimes (5–29%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Sometimes (5–29%) | In 1 condition |
| TRIM32tripartite motif containing 32 | Sometimes (5–29%) | In 1 condition |
| TTC8tetratricopeptide repeat domain 8 | Sometimes (5–29%) | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Sometimes (5–29%) | In 1 condition |
| DBHdopamine beta-hydroxylase | Rarely (1–4%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Not recorded | In 1 condition |
| CAVIN1caveolae associated protein 1 | Not recorded | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Not recorded | In 1 condition |
| GCKglucokinase | Not recorded | In 1 condition |
| GPD2glycerol-3-phosphate dehydrogenase 2 | Not recorded | In 1 condition |
| HMGA1high mobility group AT-hook 1 | Not recorded | In 1 condition |
| HNF1AHNF1 homeobox A | Not recorded | In 1 condition |
| HNF1BHNF1 homeobox B | Not recorded | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Not recorded | In 1 condition |
| IGF2BP2insulin like growth factor 2 mRNA binding protein 2 | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| IRS1insulin receptor substrate 1 | Not recorded | In 1 condition |
| IRS2insulin receptor substrate 2 | Not recorded | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Not recorded | In 1 condition |
| LIPClipase C, hepatic type | Not recorded | In 1 condition |
| MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 | Not recorded | In 1 condition |
| MTNR1Bmelatonin receptor 1B | Not recorded | In 1 condition |
| NEUROD1neuronal differentiation 1 | Not recorded | In 1 condition |
| PAX4paired box 4 | Not recorded | In 2 conditions |
| PDX1pancreatic and duodenal homeobox 1 | Not recorded | In 1 condition |
| PPP1R3Aprotein phosphatase 1 regulatory subunit 3A | Not recorded | In 1 condition |
| PTPN1protein tyrosine phosphatase non-receptor type 1 | Not recorded | In 1 condition |
| RETNresistin | Not recorded | In 1 condition |
| SLC2A2solute carrier family 2 member 2 | Not recorded | In 1 condition |
| SLC30A8solute carrier family 30 member 8 | Not recorded | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Not recorded | In 1 condition |
| TCF7L2transcription factor 7 like 2 | Not recorded | In 1 condition |
| XRCC4X-ray repair cross complementing 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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