Trait
Enlarged male breast
Clinical name: Gynecomastia
Abnormal development of large mammary glands in males resulting in breast enlargement.
Summary
- Also called
- Gynaecomastia
- Body system
- Abnormality of the breast
Reference genomeGRCh38hg38
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Get my Genome Test99 genes linked to Enlarged male breast
Changes in these genes cause rare conditions in which Enlarged male breast is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PLAAT3phospholipase A and acyltransferase 3 | Always | In 1 condition |
| RFC4replication factor C subunit 4 | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 1 condition |
| AKT2AKT serine/threonine kinase 2 | Very often (80–99%) | In 2 conditions |
| ARandrogen receptor | Very often (80–99%) | In 5 conditions |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| CYP19A1cytochrome P450 family 19 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| DHX37DEAH-box helicase 37 | Very often (80–99%) | In 1 condition |
| GATA4GATA binding protein 4 | Very often (80–99%) | In 1 condition |
| HDAC8histone deacetylase 8 | Very often (80–99%) | In 1 condition |
| LAS1LLAS1 like ribosome biogenesis factor | Very often (80–99%) | In 2 conditions |
| LEPleptin | Very often (80–99%) | In 2 conditions |
| LEPRleptin receptor | Very often (80–99%) | In 1 condition |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Very often (80–99%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Very often (80–99%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Very often (80–99%) | In 1 condition |
| PHF6PHD finger protein 6 | Very often (80–99%) | In 2 conditions |
| PNPLA6patatin like domain 6, lysophospholipase | Very often (80–99%) | In 1 condition |
| RBM28RNA binding motif protein 28 | Very often (80–99%) | In 2 conditions |
| RNF216ring finger protein 216 | Very often (80–99%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Very often (80–99%) | In 1 condition |
| SRYsex determining region Y | Very often (80–99%) | In 3 conditions |
| VAMP7vesicle associated membrane protein 7 | Very often (80–99%) | In 1 condition |
| WT1WT1 transcription factor | Very often (80–99%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Very often (80–99%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Very often (80–99%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 2 conditions |
| CPEcarboxypeptidase E | Often (30–79%) | In 1 condition |
| CUL4Bcullin 4B | Often (30–79%) | In 1 condition |
| CYP17A1cytochrome P450 family 17 subfamily A member 1 | Often (30–79%) | In 3 conditions |
| DESdesmin | Often (30–79%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Often (30–79%) | In 2 conditions |
| EMX2empty spiracles homeobox 2 | Often (30–79%) | In 2 conditions |
| FGF17fibroblast growth factor 17 | Often (30–79%) | In 2 conditions |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 2 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 3 conditions |
| FMR1fragile X messenger ribonucleoprotein 1 | Often (30–79%) | In 1 condition |
| GNRH1gonadotropin releasing hormone 1 | Often (30–79%) | In 1 condition |
Show 59 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GNRHRgonadotropin releasing hormone receptor | Often (30–79%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Often (30–79%) | In 2 conditions |
| HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Often (30–79%) | In 1 condition |
| KISS1KiSS-1 metastasis suppressor | Often (30–79%) | In 1 condition |
| KISS1RKISS1 receptor | Often (30–79%) | In 2 conditions |
| LHBluteinizing hormone subunit beta | Often (30–79%) | In 1 condition |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| NHLH2nescient helix-loop-helix 2 | Often (30–79%) | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Often (30–79%) | In 2 conditions |
| PROK2prokineticin 2 | Often (30–79%) | In 2 conditions |
| PROKR2prokineticin receptor 2 | Often (30–79%) | In 2 conditions |
| SLC29A3solute carrier family 29 member 3 | Often (30–79%) | In 2 conditions |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Often (30–79%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Often (30–79%) | In 2 conditions |
| TAC3tachykinin precursor 3 | Often (30–79%) | In 1 condition |
| TACR3tachykinin receptor 3 | Often (30–79%) | In 2 conditions |
| TCF20transcription factor 20 | Often (30–79%) | In 1 condition |
| TTI1TELO2 interacting protein 1 | Often (30–79%) | In 1 condition |
| WDR11WD repeat domain 11 | Often (30–79%) | In 2 conditions |
| ZBTB20zinc finger and BTB domain containing 20 | Often (30–79%) | In 2 conditions |
| AFF4ALF transcription elongation factor 4 | Sometimes (5–29%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Sometimes (5–29%) | In 2 conditions |
| ANOS1anosmin 1 | Sometimes (5–29%) | In 2 conditions |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Sometimes (5–29%) | In 1 condition |
| CCDC141coiled-coil domain containing 141 | Sometimes (5–29%) | In 1 condition |
| CYB5Acytochrome b5 type A | Sometimes (5–29%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Sometimes (5–29%) | In 1 condition |
| DCCDCC netrin 1 receptor | Sometimes (5–29%) | In 1 condition |
| ERMARDER membrane associated RNA degradation | Sometimes (5–29%) | In 1 condition |
| FEZF1FEZ family zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| FLRT3fibronectin leucine rich transmembrane protein 3 | Sometimes (5–29%) | In 1 condition |
| HESX1HESX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Sometimes (5–29%) | In 1 condition |
| HSD17B3hydroxysteroid 17-beta dehydrogenase 3 | Sometimes (5–29%) | In 2 conditions |
| IL17RDinterleukin 17 receptor D | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| NDNFneuron derived neurotrophic factor | Sometimes (5–29%) | In 1 condition |
| PDE11Aphosphodiesterase 11A | Sometimes (5–29%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Sometimes (5–29%) | In 2 conditions |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Sometimes (5–29%) | In 1 condition |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 2 conditions |
| RELREL proto-oncogene, NF-kB subunit | Sometimes (5–29%) | In 1 condition |
| SEMA3Asemaphorin 3A | Sometimes (5–29%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Sometimes (5–29%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Sometimes (5–29%) | In 1 condition |
| SMC5structural maintenance of chromosomes 5 | Sometimes (5–29%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Sometimes (5–29%) | In 1 condition |
| TMEM53transmembrane protein 53 | Sometimes (5–29%) | In 1 condition |
| XPO1exportin 1 | Sometimes (5–29%) | In 1 condition |
| COQ8Acoenzyme Q8A | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| CYP21A2cytochrome P450 family 21 subfamily A member 2 | Not recorded | In 1 condition |
| ITGA3integrin subunit alpha 3 | Not recorded | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Not recorded | In 1 condition |
| RSPO1R-spondin 1 | Not recorded | In 1 condition |
| STK11serine/threonine kinase 11 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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