Trait

Spontaneous milk flow from breast

Clinical name: Galactorrhea

Spontaneous flow of milk from the breast, unassociated with childbirth or nursing.

HPO HP:0100829

Also called: Galactorrhoea
Body system: Abnormality of the breast

Reference genomeGRCh38hg38

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9 genes linked to Spontaneous milk flow from breast

Changes in these genes cause rare conditions in which Spontaneous milk flow from breast is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AIPAHR interacting HSP90 co-chaperone	Very often (80–99%)	In 4 conditions
CDH23cadherin related 23	Very often (80–99%)	In 1 condition
MEN1menin 1	Very often (80–99%)	In 3 conditions
PRLRprolactin receptor	Very often (80–99%)	In 2 conditions
CDKN1Bcyclin dependent kinase inhibitor 1B	Often (30–79%)	In 1 condition
CDKN2Bcyclin dependent kinase inhibitor 2B	Often (30–79%)	In 1 condition
CD4CD4 molecule	Sometimes (5–29%)	In 1 condition
GPR101G protein-coupled receptor 101	Sometimes (5–29%)	In 1 condition
IRF4interferon regulatory factor 4	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal breast physiology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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