Trait
Glucose intolerance
Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM).
Summary
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test51 genes linked to Glucose intolerance
Changes in these genes cause rare conditions in which Glucose intolerance is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LMNAlamin A/C | Always | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Often (30–79%) | In 1 condition |
| APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Often (30–79%) | In 1 condition |
| ARMC5armadillo repeat containing 5 | Often (30–79%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| CELcarboxyl ester lipase | Often (30–79%) | In 1 condition |
| ESR1estrogen receptor 1 | Often (30–79%) | In 2 conditions |
| GCKglucokinase | Often (30–79%) | In 1 condition |
| GNASGNAS complex locus | Often (30–79%) | In 1 condition |
| HNF1AHNF1 homeobox A | Often (30–79%) | In 1 condition |
| HNF1BHNF1 homeobox B | Often (30–79%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Often (30–79%) | In 1 condition |
| INSinsulin | Often (30–79%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Often (30–79%) | In 1 condition |
| KDM1Alysine demethylase 1A | Often (30–79%) | In 1 condition |
| KLF11KLF transcription factor 11 | Often (30–79%) | In 1 condition |
| NEUROD1neuronal differentiation 1 | Often (30–79%) | In 1 condition |
| PAX4paired box 4 | Often (30–79%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Often (30–79%) | In 1 condition |
| TRMT5tRNA methyltransferase 5 | Often (30–79%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Often (30–79%) | In 1 condition |
| ALAS25'-aminolevulinate synthase 2 | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Sometimes (5–29%) | In 1 condition |
| GUK1guanylate kinase 1 | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| MTX2metaxin 2 | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Sometimes (5–29%) | In 2 conditions |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Not recorded | In 1 condition |
| APOA5apolipoprotein A5 | Not recorded | In 1 condition |
| ATMATM serine/threonine kinase | Not recorded | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| CAV1caveolin 1 | Not recorded | In 1 condition |
| ELNelastin | Not recorded | In 1 condition |
| HFEhomeostatic iron regulator | Not recorded | In 1 condition |
Show 11 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| LRP6LDL receptor related protein 6 | Not recorded | In 1 condition |
| MLXIPLMLX interacting protein like | Not recorded | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Not recorded | In 1 condition |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Not recorded | In 1 condition |
| PAX6paired box 6 | Not recorded | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Not recorded | In 1 condition |
| SLC40A1solute carrier family 40 member 1 | Not recorded | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Not recorded | In 1 condition |
| WT1WT1 transcription factor | Not recorded | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Not recorded | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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