Trait
Lack of energy and strength
Clinical name: Asthenia
A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.
Summary
- Also called
- Weakness
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Lack of energy and strength, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test27 genes linked to Lack of energy and strength
Changes in these genes cause rare conditions in which Lack of energy and strength is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALAS25'-aminolevulinate synthase 2 | Always | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| GYS1glycogen synthase 1 | Always | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Always | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| SERPINA6serpin family A member 6 | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| TUBA4Atubulin alpha 4a | Always | In 1 condition |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Very often (80–99%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Very often (80–99%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| ARHGAP19Rho GTPase activating protein 19 | Often (30–79%) | In 1 condition |
| CBLIFcobalamin binding intrinsic factor | Often (30–79%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Often (30–79%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Often (30–79%) | In 2 conditions |
| MEFVMEFV innate immunity regulator, pyrin | Often (30–79%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| DGUOKdeoxyguanosine kinase | Sometimes (5–29%) | In 1 condition |
| MSL2MSL complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| TFR2transferrin receptor 2 | Sometimes (5–29%) | In 1 condition |
| MTHFD1methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks