Trait
Left ventricular hypertrophy
Enlargement or increased size of the heart left ventricle.
Summary
- Also called
- Heart left ventricle hypertrophy, Left ventricular wall hypertrophy
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Get my Genome Test123 genes linked to Left ventricular hypertrophy
Changes in these genes cause rare conditions in which Left ventricular hypertrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALPK3alpha kinase 3 | Always | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| COG1component of oligomeric golgi complex 1 | Always | In 1 condition |
| COQ9coenzyme Q9 | Always | In 1 condition |
| COX16cytochrome c oxidase assembly factor COX16 | Always | In 1 condition |
| COX18cytochrome c oxidase assembly factor COX18 | Always | In 1 condition |
| FZR1fizzy and cell division cycle 20 related 1 | Always | In 1 condition |
| INSRinsulin receptor | Always | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| JPH2junctophilin 2 | Always | In 1 condition |
| LDB3LIM domain binding 3 | Always | In 2 conditions |
| MYH6myosin heavy chain 6 | Always | In 1 condition |
| MYL3myosin light chain 3 | Always | In 1 condition |
| NEK8NIMA related kinase 8 | Always | In 1 condition |
| NEXNnexilin F-actin binding protein | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| PLNphospholamban | Always | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Always | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Always | In 2 conditions |
| SGSM3small G protein signaling modulator 3 | Always | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Always | In 2 conditions |
| TCAPtitin-cap | Always | In 1 condition |
| TRIM63tripartite motif containing 63 | Always | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 2 conditions |
| GAAalpha glucosidase | Very often (80–99%) | In 1 condition |
| MEN1menin 1 | Very often (80–99%) | In 1 condition |
| MYL2myosin light chain 2 | Very often (80–99%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| C1QBPcomplement C1q binding protein | Often (30–79%) | In 1 condition |
| CACNA1Dcalcium voltage-gated channel subunit alpha1 D | Often (30–79%) | In 1 condition |
| ESPNespin | Often (30–79%) | In 1 condition |
| FHL1four and a half LIM domains 1 | Often (30–79%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Often (30–79%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Often (30–79%) | In 1 condition |
| MTX2metaxin 2 | Often (30–79%) | In 1 condition |
| PSEN1presenilin 1 | Often (30–79%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 1 condition |
Show 83 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SVILsupervillin | Often (30–79%) | In 1 condition |
| TLL1tolloid like 1 | Often (30–79%) | In 1 condition |
| TNNI3troponin I3, cardiac type | Often (30–79%) | In 1 condition |
| TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit | Often (30–79%) | In 1 condition |
| ABCA1ATP binding cassette subfamily A member 1 | Sometimes (5–29%) | In 2 conditions |
| ACTC1actin alpha cardiac muscle 1 | Sometimes (5–29%) | In 2 conditions |
| ACTN2actinin alpha 2 | Sometimes (5–29%) | In 1 condition |
| ADAM17ADAM metallopeptidase domain 17 | Sometimes (5–29%) | In 1 condition |
| ARSKarylsulfatase family member K | Sometimes (5–29%) | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Sometimes (5–29%) | In 1 condition |
| BIN1bridging integrator 1 | Sometimes (5–29%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Sometimes (5–29%) | In 1 condition |
| CYP11B2cytochrome P450 family 11 subfamily B member 2 | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DMDdystrophin | Sometimes (5–29%) | In 1 condition |
| FBXL4F-box and leucine rich repeat protein 4 | Sometimes (5–29%) | In 1 condition |
| FLNCfilamin C | Sometimes (5–29%) | In 1 condition |
| GLAgalactosidase alpha | Sometimes (5–29%) | In 2 conditions |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Sometimes (5–29%) | In 1 condition |
| GTPBP3GTP binding protein 3, mitochondrial | Sometimes (5–29%) | In 1 condition |
| GYS1glycogen synthase 1 | Sometimes (5–29%) | In 2 conditions |
| HCN4hyperpolarization activated cyclic nucleotide gated potassium channel 4 | Sometimes (5–29%) | In 1 condition |
| HSD11B2hydroxysteroid 11-beta dehydrogenase 2 | Sometimes (5–29%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Sometimes (5–29%) | In 1 condition |
| LOXlysyl oxidase | Sometimes (5–29%) | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Sometimes (5–29%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Sometimes (5–29%) | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| NAXDNAD(P)HX dehydratase | Sometimes (5–29%) | In 1 condition |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Sometimes (5–29%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Sometimes (5–29%) | In 1 condition |
| NONOnon-POU domain containing octamer binding | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Sometimes (5–29%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| PSEN2presenilin 2 | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Sometimes (5–29%) | In 1 condition |
| SMAD3SMAD family member 3 | Sometimes (5–29%) | In 2 conditions |
| SPEGstriated muscle enriched protein kinase | Sometimes (5–29%) | In 1 condition |
| TNNT2troponin T2, cardiac type | Sometimes (5–29%) | In 1 condition |
| TPK1thiamin pyrophosphokinase 1 | Sometimes (5–29%) | In 1 condition |
| TTNtitin | Sometimes (5–29%) | In 1 condition |
| TTRtransthyretin | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| ZNF687zinc finger protein 687 | Sometimes (5–29%) | In 1 condition |
| GLRX5glutaredoxin 5 | Rarely (1–4%) | In 1 condition |
| ZNF462zinc finger protein 462 | Rarely (1–4%) | In 1 condition |
| ARL6ARF like GTPase 6 | Not recorded | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Not recorded | In 1 condition |
| BBS1Bardet-Biedl syndrome 1 | Not recorded | In 1 condition |
| CCDC28Bcoiled-coil domain containing 28B | Not recorded | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Not recorded | In 1 condition |
| COQ7coenzyme Q7, hydroxylase | Not recorded | In 1 condition |
| DTNAdystrobrevin alpha | Not recorded | In 1 condition |
| EPG5ectopic P-granules 5 autophagy tethering factor | Not recorded | In 1 condition |
| FKRPfukutin related protein | Not recorded | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Not recorded | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Not recorded | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Not recorded | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Not recorded | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Not recorded | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Not recorded | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Not recorded | In 1 condition |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Not recorded | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Not recorded | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Not recorded | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Not recorded | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Not recorded | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Not recorded | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Not recorded | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Not recorded | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Not recorded | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Not recorded | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Not recorded | In 1 condition |
| MYOZ2myozenin 2 | Not recorded | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Not recorded | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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