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Trait

Advanced bone age

Clinical name: Accelerated skeletal maturation

An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.

HPO HP:0005616

Summary

Also called
Early bone maturation, Premature epiphyseal closure, Premature epiphyseal ossification, Premature fusion of the epiphyseal growth plate
Body system
Abnormality of the musculoskeletal system

68 genes linked to Advanced bone age

Changes in these genes cause rare conditions in which Advanced bone age is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ACANaggrecanAlwaysIn 1 condition
AMOTL1angiomotin like 1AlwaysIn 1 condition
CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1AlwaysIn 2 conditions
DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunitAlwaysIn 2 conditions
EEDembryonic ectoderm developmentAlwaysIn 1 condition
EFEMP1EGF-like fibulin extracellular matrix protein 1AlwaysIn 1 condition
EZH2enhancer of zeste 2 polycomb repressive complex 2 subunitAlwaysIn 2 conditions
GUSBglucuronidase betaAlwaysIn 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alphaAlwaysIn 2 conditions
PSMD12proteasome 26S subunit, non-ATPase 12AlwaysIn 1 condition
PTBP1polypyrimidine tract binding protein 1AlwaysIn 1 condition
TCF20transcription factor 20AlwaysIn 1 condition
TSHRthyroid stimulating hormone receptorAlwaysIn 2 conditions
AIPAHR interacting HSP90 co-chaperoneVery often (80–99%)In 1 condition
CANT1calcium activated nucleotidase 1Very often (80–99%)In 1 condition
CYP11B1cytochrome P450 family 11 subfamily B member 1Very often (80–99%)In 2 conditions
INSRinsulin receptorVery often (80–99%)In 1 condition
LHCGRluteinizing hormone/choriogonadotropin receptorVery often (80–99%)In 1 condition
MEN1menin 1Very often (80–99%)In 1 condition
NFIXnuclear factor I XVery often (80–99%)In 4 conditions
NSD1nuclear receptor binding SET domain protein 1Very often (80–99%)In 3 conditions
PDE4Dphosphodiesterase 4DVery often (80–99%)In 2 conditions
PTH1Rparathyroid hormone 1 receptorVery often (80–99%)In 2 conditions
SUZ12SUZ12 polycomb repressive complex 2 subunitVery often (80–99%)In 2 conditions
XYLT1xylosyltransferase 1Very often (80–99%)In 2 conditions
APC2APC regulator of Wnt signaling pathway 2Often (30–79%)In 1 condition
ASXL2ASXL transcriptional regulator 2Often (30–79%)In 1 condition
CYP19A1cytochrome P450 family 19 subfamily A member 1Often (30–79%)In 1 condition
GLI3GLI family zinc finger 3Often (30–79%)In 2 conditions
GNASGNAS complex locusOften (30–79%)In 1 condition
HSD11B1hydroxysteroid 11-beta dehydrogenase 1Often (30–79%)In 1 condition
KMT2Alysine methyltransferase 2AOften (30–79%)In 1 condition
LEPleptinOften (30–79%)In 1 condition
LEPRleptin receptorOften (30–79%)In 1 condition
MC4Rmelanocortin 4 receptorOften (30–79%)In 1 condition
PRKG2protein kinase cGMP-dependent 2Often (30–79%)In 1 condition
PTCH1patched 1Often (30–79%)In 1 condition
SLC26A2solute carrier family 26 member 2Often (30–79%)In 1 condition
UBE3Cubiquitin protein ligase E3COften (30–79%)In 1 condition
ABCC9ATP binding cassette subfamily C member 9Sometimes (5–29%)In 1 condition
Show 28 more genes
GeneHow often it is seenConditions
ALMS1ALMS1 centrosome and basal body associated proteinSometimes (5–29%)In 2 conditions
ARCN1archain 1 coat protein complex I subunit deltaSometimes (5–29%)In 1 condition
CAVIN1caveolae associated protein 1Sometimes (5–29%)In 1 condition
DDX6DEAD-box helicase 6Sometimes (5–29%)In 1 condition
GPC3glypican 3Sometimes (5–29%)In 2 conditions
GPC4glypican 4Sometimes (5–29%)In 1 condition
GPX4glutathione peroxidase 4Sometimes (5–29%)In 1 condition
H1-4H1.4 linker histone, cluster memberSometimes (5–29%)In 1 condition
INPPL1inositol polyphosphate phosphatase like 1Sometimes (5–29%)In 1 condition
KCNJ8potassium inwardly rectifying channel subfamily J member 8Sometimes (5–29%)In 1 condition
RMRPRNA component of mitochondrial RNA processing endoribonucleaseSometimes (5–29%)In 1 condition
RNF135ring finger protein 135Sometimes (5–29%)In 1 condition
SLC35D1solute carrier family 35 member D1Sometimes (5–29%)In 1 condition
SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2Sometimes (5–29%)In 1 condition
TET3tet methylcytosine dioxygenase 3Sometimes (5–29%)In 1 condition
B4GALT7beta-1,4-galactosyltransferase 7Rarely (1–4%)In 1 condition
AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2Not recordedIn 1 condition
B3GAT3beta-1,3-glucuronyltransferase 3Not recordedIn 1 condition
BSCL2BSCL2 lipid droplet biogenesis associated, seipinNot recordedIn 1 condition
CDKN1Ccyclin dependent kinase inhibitor 1CNot recordedIn 1 condition
CHST3carbohydrate sulfotransferase 3Not recordedIn 1 condition
GPR101G protein-coupled receptor 101Not recordedIn 1 condition
IGF2insulin like growth factor 2Not recordedIn 1 condition
KCNQ1potassium voltage-gated channel subfamily Q member 1Not recordedIn 1 condition
KCNQ1OT1KCNQ1 opposite strand/antisense transcript 1Not recordedIn 1 condition
MC2Rmelanocortin 2 receptorNot recordedIn 1 condition
MKRN3makorin ring finger protein 3Not recordedIn 1 condition
SLC10A7solute carrier family 10 member 7Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of skeletal maturation

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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