Trait

Acral overgrowth

Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargement, glove tightness, and hand enlargement.

HPO HP:0033794

Also called: Acral enlargement, Acral hypertrophy, Acromegalic growth
Body system: Growth abnormality

Reference genomeGRCh38hg38

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7 genes linked to Acral overgrowth

Changes in these genes cause rare conditions in which Acral overgrowth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AIPAHR interacting HSP90 co-chaperone	Very often (80–99%)	In 2 conditions
GPR101G protein-coupled receptor 101	Very often (80–99%)	In 2 conditions
CAVIN1caveolae associated protein 1	Often (30–79%)	In 1 condition
PLAAT3phospholipase A and acyltransferase 3	Often (30–79%)	In 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha	Often (30–79%)	In 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Sometimes (5–29%)	In 1 condition
GNASGNAS complex locus	Not recorded	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Growth abnormality

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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