Trait
Progressive loss of vision
Clinical name: Progressive visual loss
A reduction of previously attained ability to see.
Summary
- Also called
- Progressive vision loss, Progressive visual impairment, Slowly progressive visual loss, Vision loss, progressive, Visual loss, progressive, Loss of visual acuity, Progressive visual acuity loss
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Progressive loss of vision, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test122 genes linked to Progressive loss of vision
Changes in these genes cause rare conditions in which Progressive loss of vision is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDHR1cadherin related family member 1 | Always | In 2 conditions |
| CHMCHM Rab escort protein | Always | In 2 conditions |
| CLN3CLN3 lysosomal/endosomal transmembrane protein, battenin | Always | In 1 condition |
| CLN5CLN5 lysosomal BMP synthase | Always | In 1 condition |
| CLN8CLN8 transmembrane ER and ERGIC protein | Always | In 2 conditions |
| FASTKD5FASTK mitochondrial RNA regulator 5 | Always | In 1 condition |
| HMBShydroxymethylbilane synthase | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 2 conditions |
| KARS1lysyl-tRNA synthetase 1 | Always | In 1 condition |
| KIAA1549KIAA1549 | Always | In 1 condition |
| MERTKMER proto-oncogene, tyrosine kinase | Always | In 1 condition |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Always | In 2 conditions |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Always | In 1 condition |
| RPGRIP1RPGR interacting protein 1 | Always | In 2 conditions |
| TNFRSF11ATNF receptor superfamily member 11a | Always | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Very often (80–99%) | In 1 condition |
| NEU1neuraminidase 1 | Very often (80–99%) | In 2 conditions |
| OATornithine aminotransferase | Very often (80–99%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Very often (80–99%) | In 2 conditions |
| PRPH2peripherin 2 | Very often (80–99%) | In 2 conditions |
| RDH11retinol dehydrogenase 11 | Very often (80–99%) | In 1 condition |
| RDH5retinol dehydrogenase 5 | Very often (80–99%) | In 1 condition |
| RHOrhodopsin | Very often (80–99%) | In 1 condition |
| RLBP1retinaldehyde binding protein 1 | Very often (80–99%) | In 2 conditions |
| RS1retinoschisin 1 | Very often (80–99%) | In 2 conditions |
| ABCA4ATP binding cassette subfamily A member 4 | Often (30–79%) | In 1 condition |
| ADAM9ADAM metallopeptidase domain 9 | Often (30–79%) | In 1 condition |
| AGTPBP1ATP/GTP binding carboxypeptidase 1 | Often (30–79%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| AIPL1AIP like 1 HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| ATF6activating transcription factor 6 | Often (30–79%) | In 1 condition |
| CACNA1Fcalcium voltage-gated channel subunit alpha1 F | Often (30–79%) | In 1 condition |
| CACNA2D4calcium voltage-gated channel auxiliary subunit alpha2delta 4 | Often (30–79%) | In 1 condition |
| CARS2cysteinyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 2 conditions |
| CEP164centrosomal protein 164 | Often (30–79%) | In 1 condition |
| CEP290centrosomal protein 290 | Often (30–79%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Often (30–79%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Often (30–79%) | In 2 conditions |
| CNGA3cyclic nucleotide gated channel subunit alpha 3 | Often (30–79%) | In 1 condition |
Show 82 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| COL18A1collagen type XVIII alpha 1 chain | Often (30–79%) | In 1 condition |
| CRXcone-rod homeobox | Often (30–79%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| DRAM2DNA damage regulated autophagy modulator 2 | Often (30–79%) | In 1 condition |
| EXOSC3exosome component 3 | Often (30–79%) | In 1 condition |
| EXOSC8exosome component 8 | Often (30–79%) | In 1 condition |
| EXOSC9exosome component 9 | Often (30–79%) | In 1 condition |
| FSD1Lfibronectin type III and SPRY domain containing 1 like | Often (30–79%) | In 1 condition |
| GUCA1Aguanylate cyclase activator 1A | Often (30–79%) | In 2 conditions |
| GUCY2Dguanylate cyclase 2D, retinal | Often (30–79%) | In 1 condition |
| IFT54intraflagellar transport 54 | Often (30–79%) | In 1 condition |
| INVSinversin | Often (30–79%) | In 1 condition |
| IQCB1IQ motif containing B1 | Often (30–79%) | In 1 condition |
| LRP2LDL receptor related protein 2 | Often (30–79%) | In 2 conditions |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| MFSD8major facilitator superfamily domain containing 8 | Often (30–79%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Often (30–79%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Often (30–79%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Often (30–79%) | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Often (30–79%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Often (30–79%) | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Often (30–79%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Often (30–79%) | In 1 condition |
| MT-ND4Lmitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L | Often (30–79%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Often (30–79%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Often (30–79%) | In 1 condition |
| MTTPmicrosomal triglyceride transfer protein | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| NMNAT1nicotinamide nucleotide adenylyltransferase 1 | Often (30–79%) | In 1 condition |
| NPHP1nephrocystin 1 | Often (30–79%) | In 1 condition |
| NPHP3nephrocystin 3 | Often (30–79%) | In 1 condition |
| NPHP4nephrocystin 4 | Often (30–79%) | In 1 condition |
| OPN1LWopsin 1, long wave sensitive | Often (30–79%) | In 1 condition |
| OPN1MWopsin 1, medium wave sensitive | Often (30–79%) | In 1 condition |
| PAK2p21 (RAC1) activated kinase 2 | Often (30–79%) | In 1 condition |
| PITPNM3PITPNM family member 3 | Often (30–79%) | In 1 condition |
| POC1BPOC1 centriolar protein B | Often (30–79%) | In 1 condition |
| PROM1prominin 1 | Often (30–79%) | In 1 condition |
| RAB28RAB28, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RAX2retina and anterior neural fold homeobox 2 | Often (30–79%) | In 1 condition |
| RIMS1regulating synaptic membrane exocytosis 1 | Often (30–79%) | In 1 condition |
| RPGRretinitis pigmentosa GTPase regulator | Often (30–79%) | In 1 condition |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Often (30–79%) | In 1 condition |
| SEMA4Asemaphorin 4A | Often (30–79%) | In 2 conditions |
| SLC25A46solute carrier family 25 member 46 | Often (30–79%) | In 2 conditions |
| TLCD3BTLC domain containing 3B | Often (30–79%) | In 1 condition |
| TTLL5tubulin tyrosine ligase like 5 | Often (30–79%) | In 1 condition |
| UBAP1Lubiquitin associated protein 1 like | Often (30–79%) | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| UNC119unc-119 lipid binding chaperone | Often (30–79%) | In 1 condition |
| VRK1VRK serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| WDR19WD repeat domain 19 | Often (30–79%) | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Sometimes (5–29%) | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Sometimes (5–29%) | In 1 condition |
| SH3BP2SH3 domain binding protein 2 | Sometimes (5–29%) | In 1 condition |
| SONSON DNA and RNA binding protein | Sometimes (5–29%) | In 1 condition |
| APOEapolipoprotein E | Not recorded | In 1 condition |
| ARL3ARF like GTPase 3 | Not recorded | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Not recorded | In 1 condition |
| ATXN7ataxin 7 | Not recorded | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Not recorded | In 1 condition |
| C19orf12chromosome 19 open reading frame 12 | Not recorded | In 1 condition |
| CFHcomplement factor H | Not recorded | In 1 condition |
| CFHR1complement factor H related 1 | Not recorded | In 1 condition |
| CFHR3complement factor H related 3 | Not recorded | In 1 condition |
| CFIcomplement factor I | Not recorded | In 1 condition |
| CLN6CLN6 transmembrane ER protein | Not recorded | In 1 condition |
| CYP4V2cytochrome P450 family 4 subfamily V member 2 | Not recorded | In 1 condition |
| DCNdecorin | Not recorded | In 1 condition |
| EPRS1glutamyl-prolyl-tRNA synthetase 1 | Not recorded | In 1 condition |
| HMCN1hemicentin 1 | Not recorded | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Not recorded | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Not recorded | In 1 condition |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Not recorded | In 1 condition |
| PNPLA6patatin like domain 6, lysophospholipase | Not recorded | In 1 condition |
| PPT1palmitoyl-protein thioesterase 1 | Not recorded | In 1 condition |
| SOSTsclerostin | Not recorded | In 1 condition |
| TGFBItransforming growth factor beta induced | Not recorded | In 1 condition |
| TPP1tripeptidyl peptidase 1 | Not recorded | In 1 condition |
| TREX1three prime repair exonuclease 1 | Not recorded | In 1 condition |
| ZNF408zinc finger protein 408 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks