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Trait
Adrenal insufficiency
Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.
Summary
- Also called
- Hypoadrenalism
- Body system
- Abnormality of the endocrine system
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/adrenal-insufficiency.json"
page <- fromJSON(url)
page$trait$nameAdrenal insufficiencyHP:0000846
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Get my Genome Test47 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Familial Glucocorticoid DeficiencyReads 6 of these genesMC2RMRAPNNTTXNRD2AAASNR0B1About this report →
- 46,XY Differences of Sex Development and Gonadal DysgenesisReads 8 of these genesDHX37GATA4MAP3K1NR5A1SRYWT1About this report →
- Congenital Adrenal HyperplasiaReads 4 of these genesSTARPORHSD3B2CYP11A1About this report →
- Familial Isolated Pituitary Adenoma (FIPA / X-LAG)Reads 2 of these genesAIPGPR101About this report →
Show 43 more reports
- 46,XX Differences of Sex DevelopmentReads 2 of these genesNR5A1SRYAbout this report →
- Alacrima, Achalasia and Intellectual Disability Syndrome (GMPPA)Reads 1 of these genesGMPPAAbout this report →
- Autoimmune Polyendocrine Syndrome Type 1 (APECED)Reads 1 of these genesAIREAbout this report →
- Campomelic DysplasiaReads 1 of these genesSOX9About this report →
- Glycerol Kinase DeficiencyReads 1 of these genesGKAbout this report →
- Lysosomal Acid Lipase Deficiency (Wolman Disease and CESD)Reads 1 of these genesLIPAAbout this report →
- Sickle Cell DiseaseReads 1 of these genesHBBAbout this report →
- X-Linked Adrenoleukodystrophy (ABCD1)Reads 1 of these genesABCD1About this report →
- Hereditary Wilms TumourReads 1 of these genesWT1About this report →
- Hypertrophic CardiomyopathyReads 5 of these genesDHX37MAP3K1NR5A1SRYZFPM2About this report →
- Congenital Diaphragmatic Hernia (Monogenic)Reads 1 of these genesZFPM2About this report →
- Monogenic Precocious PubertyReads 1 of these genesMKRN3About this report →
- Tetralogy of FallotReads 1 of these genesZFPM2About this report →
- Hypogonadotropic HypogonadismReads 4 of these genesNR0B1MAGEL2LHX4PROP1About this report →
- Zellweger Spectrum & Peroxisome Biogenesis DisordersReads 2 of these genesPEX5PEX6About this report →
- Inherited Predisposition to Myeloid Blood CancersReads 1 of these genesSAMD9About this report →
- Hereditary Methaemoglobinaemia and Unstable HaemoglobinsReads 1 of these genesHBBAbout this report →
- ThalassaemiaReads 1 of these genesHBBAbout this report →
- Non-Acquired Combined Pituitary Hormone DeficiencyReads 2 of these genesLHX4PROP1About this report →
- Monogenic Obesity (Leptin-Melanocortin Pathway)Reads 1 of these genesPOMCAbout this report →
- PolycythemiaReads 1 of these genesHBBAbout this report →
- Other Inherited LeukodystrophiesReads 3 of these genesABCD1PEX5PEX6About this report →
- Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-WiedemannReads 1 of these genesMAGEL2About this report →
- Inherited Congenital Heart DefectsReads 1 of these genesGATA4About this report →
- Female InfertilityReads 2 of these genesSTARNR5A1About this report →
- Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)Reads 2 of these genesWWOXPEX6About this report →
- Neonatal Diabetes MellitusReads 1 of these genesGATA4About this report →
- Autoimmune DiseaseReads 1 of these genesAIREAbout this report →
- Syndromic CraniosynostosisReads 1 of these genesPORAbout this report →
- Inherited Neurodegenerative DisordersReads 4 of these genesABCD1WWOXPEX5PEX6About this report →
- Rare Hereditary Peripheral NeuropathiesReads 3 of these genesNDUFAF5PEX5PEX6About this report →
- Microphthalmia, Anophthalmia & ColobomaReads 1 of these genesBCORAbout this report →
- Nephrotic SyndromeReads 1 of these genesSGPL1About this report →
- Diabetes MellitusReads 1 of these genesGATA4About this report →
- Thyroid CancerReads 1 of these genesAIREAbout this report →
- Limb-Girdle Muscular DystrophyReads 1 of these genesTRAPPC11About this report →
- Primary Mitochondrial DiseaseReads 2 of these genesNDUFAF5NFS1About this report →
- Lysosomal Storage DiseaseReads 1 of these genesLIPAAbout this report →
- Hereditary Spastic ParaplegiaReads 1 of these genesABCD1About this report →
- Leigh SyndromeReads 1 of these genesNDUFAF5About this report →
- Epilepsy (Full Panel)Reads 1 of these genesWWOXAbout this report →
- Other Inborn Errors of ImmunityReads 1 of these genesMCM4About this report →
- Intellectual DisabilityReads 1 of these genesKDM6BAbout this report →
Read the genes linked to Adrenal insufficiency, and the rest of your genome, with one test.
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Get my Genome Test53 genes linked to Adrenal insufficiency
Changes in these genes cause rare conditions in which Adrenal insufficiency is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GKglycerol kinase | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| LIPAlipase A, lysosomal acid type | Always | In 2 conditions |
| MC2Rmelanocortin 2 receptor | Always | In 1 condition |
| MCM4minichromosome maintenance complex component 4 | Always | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Always | In 1 condition |
| MRPS25mitochondrial ribosomal protein S25 | Always | In 1 condition |
| NDUFAF5NADH:ubiquinone oxidoreductase complex assembly factor 5 | Always | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Always | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Always | In 1 condition |
| STARsteroidogenic acute regulatory protein | Always | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Always | In 1 condition |
| AAASaladin WD repeat nucleoporin | Very often (80–99%) | In 2 conditions |
| GMPPAGDP-mannose pyrophosphorylase A | Very often (80–99%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Very often (80–99%) | In 1 condition |
| AIREautoimmune regulator | Often (30–79%) | In 1 condition |
| NFS1NFS1 cysteine desulfurase | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| DHX37DEAH-box helicase 37 | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| GATA4GATA binding protein 4 | Sometimes (5–29%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Sometimes (5–29%) | In 1 condition |
| HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Sometimes (5–29%) | In 1 condition |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Sometimes (5–29%) | In 2 conditions |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| SRYsex determining region Y | Sometimes (5–29%) | In 1 condition |
| STEAP3STEAP3 metalloreductase | Sometimes (5–29%) | In 1 condition |
| VAMP7vesicle associated membrane protein 7 | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Sometimes (5–29%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Sometimes (5–29%) | In 1 condition |
| HBBhemoglobin subunit beta | Rarely (1–4%) | In 3 conditions |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Rarely (1–4%) | In 1 condition |
| MAGEL2MAGE family member L2 | Rarely (1–4%) | In 1 condition |
| MKRN3makorin ring finger protein 3 | Rarely (1–4%) | In 1 condition |
Show 13 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NPAP1nuclear pore associated protein 1 | Rarely (1–4%) | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Rarely (1–4%) | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Rarely (1–4%) | In 1 condition |
| SAA1serum amyloid A1 | Rarely (1–4%) | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Rarely (1–4%) | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Rarely (1–4%) | In 1 condition |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Not recorded | In 1 condition |
| LHX4LIM homeobox 4 | Not recorded | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Not recorded | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Not recorded | In 1 condition |
| POMCproopiomelanocortin | Not recorded | In 1 condition |
| PROP1PROP paired-like homeobox 1 | Not recorded | In 1 condition |
| SGPL1sphingosine-1-phosphate lyase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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