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Trait

Premature pubic hair growth

Clinical name: Premature pubarche

The onset of growth of pubic hair at an earlier age than normal.

HPO HP:0012411

Summary

Body system
Abnormality of the endocrine system

13 genes linked to Premature pubic hair growth

Changes in these genes cause rare conditions in which Premature pubic hair growth is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AIPAHR interacting HSP90 co-chaperoneVery often (80–99%)In 1 condition
MEN1menin 1Very often (80–99%)In 1 condition
CYP11B1cytochrome P450 family 11 subfamily B member 1Often (30–79%)In 1 condition
HSD11B1hydroxysteroid 11-beta dehydrogenase 1Often (30–79%)In 1 condition
MAGEL2MAGE family member L2Often (30–79%)In 4 conditions
NDNnecdin, MAGE family memberOften (30–79%)In 3 conditions
OCA2OCA2 melanosomal transmembrane proteinOften (30–79%)In 3 conditions
SNRPNsmall nuclear ribonucleoprotein polypeptide NOften (30–79%)In 3 conditions
SIM1SIM bHLH transcription factor 1Sometimes (5–29%)In 1 condition
TANGO2transport and golgi organization 2 homologSometimes (5–29%)In 1 condition
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2Not recordedIn 1 condition
MKRN3makorin ring finger protein 3Not recordedIn 1 condition
PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Early onset of puberty

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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