Traits

Traits linked to TP53

tumor protein p53

The Human Phenotype Ontology links 214 traits to TP53, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Ne sıklıkla görüldüğü
Choroid plexus carcinoma	Her zaman
Global developmental delay	Her zaman
Intellectual disability	Her zaman
Abnormal shape of nervous system	Çok sık (%80–99)
Pins and needles feeling	Çok sık (%80–99)
Too much cerebrospinal fluid in the brain	Çok sık (%80–99)
Anxiety	Sık (%30–79)
Behavioral abnormality	Sık (%30–79)
Can't control feelings	Sık (%30–79)
Difficulty staying or falling asleep	Sık (%30–79)
Grand mal seizures	Sık (%30–79)
Headache	Sık (%30–79)
Irritability	Sık (%30–79)
Migraine	Sık (%30–79)
Panic attack	Sık (%30–79)
Astrocytoma	Bazen (%5–29)
Cognitive impairment	Bazen (%5–29)
Depression	Bazen (%5–29)
Ependymoma	Bazen (%5–29)
Epilepsy	Bazen (%5–29)
Glioblastoma multiforme	Bazen (%5–29)
Memory impairment	Bazen (%5–29)
Paralysis or weakness of one side of body	Bazen (%5–29)
Psychotic episodes	Bazen (%5–29)
Suicidal ideation	Bazen (%5–29)
Tumors of the central nervous system	Bazen (%5–29)
Dementia	Seyrek (%1–4)
Medulloblastoma	Seyrek (%1–4)
Paranoia	Seyrek (%1–4)
Psychosis	Seyrek (%1–4)

Abnormality of blood and blood-forming tissues

Trait	Ne sıklıkla görüldüğü
Erythroid hypoplasia	Her zaman
Low number of red blood cells or hemoglobin	Her zaman
Pure red cell aplasia	Her zaman
Abnormal shape of platelets	Çok sık (%80–99)
Blood clot in artery	Çok sık (%80–99)
Blood clot in vein	Çok sık (%80–99)
Bone marrow disease	Çok sık (%80–99)
Increased megakaryocyte count	Çok sık (%80–99)
Increased number of platelets in blood	Çok sık (%80–99)
Megakaryocyte nucleus hyperlobulation	Çok sık (%80–99)
Platelet abnormalities	Çok sık (%80–99)
Prolonged bleeding time	Çok sık (%80–99)
Bleeding tendency	Sık (%30–79)
Bruising susceptibility	Sık (%30–79)
Decreased blood lymphocyte number	Sık (%30–79)
Decreased total eosinophil count	Sık (%30–79)
Elevated white blood count	Sık (%30–79)
Acute blood cancer	Bazen (%5–29)
Blood cancer	Bazen (%5–29)
Blood clot in liver vein	Bazen (%5–29)
Blood spots	Bazen (%5–29)
Cancer of lymphatic system	Bazen (%5–29)
Ecchymosis	Bazen (%5–29)
Myelodysplasia	Bazen (%5–29)
Myelofibrosis	Bazen (%5–29)
Acute lymphoblastic leukemia	Seyrek (%1–4)
Acute myeloid leukemia	Seyrek (%1–4)
Hodgkin lymphoma	Seyrek (%1–4)
Non-Hodgkin lymphoma	Seyrek (%1–4)

Abnormality of the digestive system

Trait	Ne sıklıkla görüldüğü
Pancreatic adenocarcinoma	Her zaman
Abdominal pain	Çok sık (%80–99)
Anorexia	Çok sık (%80–99)
Inability to properly digest food due to lack of pancreatic digestive enzymes	Çok sık (%80–99)
Poor appetite	Çok sık (%80–99)
Primary peritoneal carcinoma	Çok sık (%80–99)
Extrahepatic cholestasis	Sık (%30–79)
Functional intestinal obstruction	Sık (%30–79)
Intestinal pseudo-obstruction	Sık (%30–79)
Jaundice	Sık (%30–79)
Cancer of the pancreas	Bazen (%5–29)
Colon cancer	Bazen (%5–29)
Colorectal polyposis	Bazen (%5–29)
Gastrointestinal tract tumor	Bazen (%5–29)
Intermittent diarrhea	Bazen (%5–29)
Liver cancer	Bazen (%5–29)
Nausea and vomiting	Bazen (%5–29)
Peritoneal abscess	Bazen (%5–29)
Stomach cancer	Bazen (%5–29)
Rectal tumor	Seyrek (%1–4)
Hepatocellular carcinoma	Kaydedilmedi
Hereditary nonpolyposis colorectal carcinoma	Kaydedilmedi
Micronodular cirrhosis	Kaydedilmedi
Nausea	Kaydedilmedi
Stomach tumor	Kaydedilmedi
Subacute progressive viral hepatitis	Kaydedilmedi
Vomiting	Kaydedilmedi

Abnormality of the genitourinary system

Trait	Ne sıklıkla görüldüğü
Abnormal fallopian tube morphology	Çok sık (%80–99)
Ovarian cancer	Çok sık (%80–99)
Abnormal absence of menstruation	Sık (%30–79)
Abnormality of reproductive system physiology	Sık (%30–79)
Testicular degeneration	Sık (%30–79)
Abnormal libido	Bazen (%5–29)
Light or infrequent menstrual periods	Bazen (%5–29)
Ovarian carcinoma	Bazen (%5–29)
Previous menstrual periods stop	Bazen (%5–29)
Prostate cancer	Bazen (%5–29)
Kidney cancer	Seyrek (%1–4)
Testicular cancer	Seyrek (%1–4)
Cancer starting in small tubes in kidneys	Kaydedilmedi
Nephroblastoma	Kaydedilmedi
Prostate neoplasm	Kaydedilmedi
Transitional cell carcinoma of the bladder	Kaydedilmedi
Uterine leiomyosarcoma	Kaydedilmedi

Abnormality of the endocrine system

Trait	Ne sıklıkla görüldüğü
Adrenocortical carcinoma	Her zaman
Decreased activity of gonads	Her zaman
Increased circulating cortisol level	Çok sık (%80–99)
Paradoxical increased cortisol secretion on dexamethasone suppression test	Çok sık (%80–99)
Pituitary corticotropic cell adenoma	Çok sık (%80–99)
Abnormal circulating dehydroepiandrosterone concentration	Sık (%30–79)
Adrenocorticotropic hormone deficiency	Sık (%30–79)
Elevated plasma aldosterone	Sık (%30–79)
Elevated serum 11-deoxycortisol	Sık (%30–79)
Enlarged adrenal glands	Sık (%30–79)
Increased circulating ACTH level	Sık (%30–79)
Increased circulating androgen concentration	Sık (%30–79)
Increased circulating androstenedione concentration	Sık (%30–79)
Increased serum estradiol	Sık (%30–79)
Thyroid carcinoma	Seyrek (%1–4)

Abnormality of the integument

Trait	Ne sıklıkla görüldüğü
Choroid plexus papilloma	Her zaman
Reticular hyperpigmentation	Her zaman
Buffalo hump	Sık (%30–79)
Excessive hair growth	Sık (%30–79)
Excessive hairiness	Sık (%30–79)
Excessive sweating	Sık (%30–79)
Patchy darkened skin	Sık (%30–79)
Plethora	Sık (%30–79)
Poor wound healing	Sık (%30–79)
Stretch marks	Sık (%30–79)
Thin skin	Sık (%30–79)
Flushing	Bazen (%5–29)
Open skin sore	Bazen (%5–29)
Basal cell carcinoma	Kaydedilmedi

Abnormality of the musculoskeletal system

Trait	Ne sıklıkla görüldüğü
Bone cell cancer	Her zaman
Back pain	Çok sık (%80–99)
Breakdown of bone	Çok sık (%80–99)
Delayed bone maturation	Sık (%30–79)
Fatiguable weakness of proximal limb muscles	Sık (%30–79)
Muscle weakness	Sık (%30–79)
Osteoporosis	Sık (%30–79)
Wasting of muscles near the body	Sık (%30–79)
Compression fracture of a vertebral body	Bazen (%5–29)
Rhabdomyosarcoma	Bazen (%5–29)
Spasticity and rigidity of muscles	Bazen (%5–29)
Death of bone due to decreased blood supply	Seyrek (%1–4)
Spontaneous fracture	Seyrek (%1–4)

Laboratory abnormality

Trait	Ne sıklıkla görüldüğü
High urine cortisol level	Çok sık (%80–99)
Abnormal circulating lactate dehydrogenase concentration	Sık (%30–79)
Diabetes mellitus	Sık (%30–79)
Elevated alkaline phosphatase	Sık (%30–79)
Impaired glucose tolerance	Sık (%30–79)
Increased circulating lactate dehydrogenase concentration	Sık (%30–79)
Joint swelling	Sık (%30–79)
Laboratory abnormality	Sık (%30–79)
Low blood potassium levels	Sık (%30–79)
High liver enzymes	Bazen (%5–29)
Pee issues	Bazen (%5–29)
Fever	Seyrek (%1–4)
Increased level of L-fucose in urine	Kaydedilmedi

Abnormality of the cardiovascular system

Trait	Ne sıklıkla görüldüğü
Abnormality of the cerebral blood vessels	Çok sık (%80–99)
Heart attack	Çok sık (%80–99)
Abnormality of the cardiovascular system	Sık (%30–79)
Capillary fragility	Sık (%30–79)
High blood pressure	Sık (%30–79)
Increased spleen size	Sık (%30–79)
Palpitations	Sık (%30–79)
Swollen lymph nodes	Sık (%30–79)
Enlarged liver and spleen	Bazen (%5–29)
Livedo reticularis	Bazen (%5–29)
Mini stroke	Bazen (%5–29)
Stroke	Bazen (%5–29)

Abnormality of head or neck

Trait	Ne sıklıkla görüldüğü
Abnormally small head	Her zaman
Dark color of gums	Sık (%30–79)
Moon face	Sık (%30–79)
Big sella turcica	Bazen (%5–29)
Sparse scalp hair	Bazen (%5–29)
Neoplasia of the nasopharynx	Kaydedilmedi

Abnormality of the eye

Trait	Ne sıklıkla görüldüğü
Amaurosis fugax	Çok sık (%80–99)
Visual impairment	Bazen (%5–29)
Optic nerve compression	Seyrek (%1–4)
Partial loss of field of vision	Seyrek (%1–4)
Papilledema	Kaydedilmedi
Retina tumor	Kaydedilmedi

Growth abnormality

Trait	Ne sıklıkla görüldüğü
Growth delay	Her zaman
Short stature	Her zaman
Weight loss	Çok sık (%80–99)
Abdominal obesity	Sık (%30–79)
Increased body weight	Sık (%30–79)
Truncal obesity	Sık (%30–79)

Abnormal tissue mass

Trait	Ne sıklıkla görüldüğü
Abnormal tissue mass	Çok sık (%80–99)
Cancer of skin pigment cells	Bazen (%5–29)
Central primitive neuroectodermal tumor	Bazen (%5–29)
Head and neck tumor	Seyrek (%1–4)
Soft tissue sarcoma	Kaydedilmedi

Constitutional symptom

Trait	Ne sıklıkla görüldüğü
Chest pain	Çok sık (%80–99)
Chronic fatigue	Çok sık (%80–99)
Fatigue	Çok sık (%80–99)
Pain	Sık (%30–79)
Erythromelalgia	Bazen (%5–29)

Abnormality of limbs

Trait	Ne sıklıkla görüldüğü
Abnormality of the wide portion of the femoral bone	Çok sık (%80–99)
Abnormality of the wide portion of a long bone	Sık (%30–79)
Abnormality of the wide portion of shankbone	Sık (%30–79)
Fluid accumulation in lower limbs	Seyrek (%1–4)

Abnormality of the respiratory system

Trait	Ne sıklıkla görüldüğü
Lung adenocarcinoma	Sık (%30–79)
Abnormality of the respiratory system	Bazen (%5–29)
Lung cancer	Seyrek (%1–4)
Neoplasm of the larynx	Seyrek (%1–4)

Abnormality of the immune system

Trait	Ne sıklıkla görüldüğü
Acne	Sık (%30–79)
Decreased immune function	Sık (%30–79)
Recurrent cutaneous fungal infections	Bazen (%5–29)

Abnormal cellular phenotype

Trait	Ne sıklıkla görüldüğü
Decreased circulating antibody level	Her zaman
Short telomere length	Her zaman

Abnormality of prenatal development or birth

Trait	Ne sıklıkla görüldüğü
Choriocarcinoma	Seyrek (%1–4)

Abnormality of the breast

Trait	Ne sıklıkla görüldüğü
Breast cancer	Sık (%30–79)

Abnormality of the ear

Trait	Ne sıklıkla görüldüğü
Dizziness	Sık (%30–79)

Bu özelliğin, genin ilişkili olduğu durumlardan birine sahip kişiler arasında ne sıklıkta görüldüğü; Human Phenotype Ontology'nin kaydettiği şekliyle, bunlar arasında en sık görülen oran. Bu sayfalar özellikleri ve bunların arkasındaki araştırmaları anlatır; tanı koymaz. Belirtiler hakkında bir doktora veya genetik danışmana başvurmanız gerekir.

Bilgilerin kaynağı

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TP53 and how often each is seen. Find out more at hpo.jax.org.

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