Gene
HYLS1
HYLS1 centriolar and ciliogenesis associated
- HGNC 26558(opens in a new tab)
- Ensembl gene ENSG00000198331(opens in a new tab)
- NCBI Gene 219844(opens in a new tab)
Summary
- Cytogenetic location
- 11q24.2
- Coordinates
- Chromosome 11: 125,887,668–125,900,646 (GRCh38)
- Exons
- 3 exons across 13 kb
- Protein
- 299 amino acids
- Also known as
- FLJ32915
- MANE Select transcript
- ENST00000425380.7NM_001134793.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads HYLS1 yet. The test sequences your whole genome, so your data includes it all the same.
How HYLS1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.5 kb of the gene's 13 kb; 900 of those bases code for the protein.
How a genome test reads HYLS1
24
positions in HYLS1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 13 kb of HYLS1, introns included, not only the 1.5 kb of exons.
Traits linked to HYLS1
The Human Phenotype Ontology lists these as features of the rare conditions HYLS1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of limbs
- Extra little finger
- Club feet
- Extra thumb
- Duplication of bones of the toes
- Extra finger
- Smaller or shorter than typical limbs
- Duplication of big toe bone
- Proximal tibial hypoplasia
Show 1 more trait
Abnormality of the respiratory system
- Abnormal pattern of respiration
- Apnea
- Episodic tachypnea
- Abnormal lung lobation
- Abnormality of the respiratory system
- Laryngeal hypoplasia
- Narrowing of windpipe
- Softening of voice box tissue
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). HYLS1 gene: HYLS1 centriolar and ciliogenesis associated. Retrieved 17 October 2026, from https://dantelabs.com/genes/hyls1
Dante Labs. HYLS1 gene: HYLS1 centriolar and ciliogenesis associated [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hyls1
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