Gene
ERMARD
ER membrane associated RNA degradation
- HGNC 21056↗(opens in a new tab)
- Ensembl gene ENSG00000130023↗(opens in a new tab)
- NCBI Gene 55780↗(opens in a new tab)
Summary
- Cytogenetic location
- 6q27
- Coordinates
- Chromosome 6: 169,751,622–169,781,600 (GRCh38)
- Exons
- 18 exons across 30 kb
- Protein
- 678 amino acids
- Also known as
- FLJ11152, dJ266L20.3
- Previous symbols
- C6orf70
- MANE Select transcript
- ENST00000366773.8NM_018341.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads ERMARD yet. The test sequences your whole genome, so your data includes it all the same.
How ERMARD is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.2 kb of the gene's 30 kb; 2,037 of those bases code for the protein.
How a genome test reads ERMARD
2
positions in ERMARD where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 30 kb of ERMARD, introns included, not only the 2.2 kb of exons.
Traits linked to ERMARD
The Human Phenotype Ontology lists these as features of the rare conditions ERMARD can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Delayed speech and language development
- Epilepsy
- Focal motor seizure
- Hypsarrhythmia
- Infantile spasms
- Mild global developmental delay
- Periventricular nodular heterotopia
- Abnormal cerebral cortex morphology
Show 14 more traits
- Abnormal cerebral white matter morphology
- Abnormality of neuronal migration
- Colpocephaly
- Global developmental delay
- Gray matter heterotopia
- Intellectual disability, mild
- More grooves in brain
- Periventricular heterotopia
- Small cerebellum
- Underdevelopment of part of brain called corpus callosum
- Abnormal shape of nervous system
- Inability to coordinate movements when walking
- Lack of coordination of movement
- Seizure affecting one half of brain
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). ERMARD gene: ER membrane associated RNA degradation. Retrieved 17 October 2026, from https://dantelabs.com/genes/ermard
Dante Labs. ERMARD gene: ER membrane associated RNA degradation [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ermard
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