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Gene

IFT74

intraflagellar transport 74

Summary

Cytogenetic location
9p21.2
Coordinates
Chromosome 9: 26,956,412–27,066,134 (GRCh38)
Exons
20 exons across 109.7 kb
Protein
600 amino acids
Inheritance
Autosomal recessive
Also known as
CMG1, CMG-1, FLJ22621
Previous symbols
CCDC2
MANE Select transcript
ENST00000380062.10NM_025103.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Bardet-Biedl and Alström Syndromes

    • Bardet-Biedl syndromeAutosomal recessive

      A recessive ciliopathy caused by variants in more than 20 genes (most often BBS1 and BBS10) that causes retinal dystrophy, obesity, extra fingers or toes, kidney anomalies and learning difficulties.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis allows eye, kidney and diabetes surveillance, and setmelanotide is an approved treatment for obesity in Bardet-Biedl syndrome.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How IFT74 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where IFT74 sits. IFT74 and 6 genes near it on chromosome 9, from 26,511,273 to 27,511,272.Chromosome 99p21.2p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.326.6 Mb26.8 Mb27 Mb27.2 Mb27.4 MbCAAP1: 26,837,785–26,892,824, reverse strandCAAP1PLAA: 26,903,359–26,947,495, reverse strandPLAAIFT74: 26,956,412–27,066,134, forward strandIFT74LRRC19: 26,993,136–27,005,709, reverse strandLRRC19TEK: 27,109,030–27,232,092, forward strandTEKEQTN: 27,284,654–27,297,150, reverse strandEQTNMOB3B: 27,325,209–27,529,829, reverse strandMOB3BDiagram of IFT74: 20 exons on the forward strand of chromosome 9Exon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 1: 26,956,412–26,956,516, 105 basesExon 2: 26,961,949–26,962,087, 139 basesExon 3: 26,978,128–26,978,263, 136 basesExon 4: 26,980,571–26,980,619, 49 basesExon 5: 26,984,257–26,984,355, 99 basesExon 6: 26,984,499–26,984,559, 61 basesExon 7: 26,988,669–26,988,728, 60 basesExon 8: 26,990,134–26,990,195, 62 basesExon 9: 27,009,020–27,009,158, 139 basesExon 10: 27,011,906–27,011,968, 63 basesExon 11: 27,016,907–27,017,050, 144 basesExon 12: 27,018,647–27,018,687, 41 basesExon 13: 27,029,025–27,029,104, 80 basesExon 14: 27,044,742–27,044,795, 54 basesExon 15: 27,047,274–27,047,371, 98 basesExon 16: 27,048,148–27,048,274, 127 basesExon 17: 27,055,609–27,055,772, 164 basesExon 18: 27,056,334–27,056,459, 126 basesExon 19: 27,060,591–27,060,651, 61 basesExon 20: 27,062,618–27,066,134, 3,517 bases124681012141618205′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.3 kb of the gene's 109.7 kb; 1,803 of those bases code for the protein.

How a genome test reads IFT74

8

positions in IFT74 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 109.7 kb of IFT74, introns included, not only the 5.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IFT74 gene: intraflagellar transport 74. Retrieved 16 October 2026, from https://dantelabs.com/genes/ift74

Vancouver

Dante Labs. IFT74 gene: intraflagellar transport 74 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ift74

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