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Gene

TCP1

t-complex 1

Summary

Cytogenetic location
6q25.3
Coordinates
Chromosome 6: 159,778,498–159,789,602 (GRCh38)
Exons
12 exons across 11.1 kb
Protein
556 amino acids
Also known as
D6S230E, CCT1, Ccta
MANE Select transcript
ENST00000321394.12NM_030752.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How TCP1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 6, with a bracket where TCP1 sits. TCP1 and 9 genes near it on chromosome 6, from 159,284,050 to 160,284,049.Chromosome 66q25.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27159.4 Mb159.6 Mb159.8 Mb160 Mb160.2 MbSOD2: 159,569,593–159,762,529, reverse strandSOD2WTAP: 159,716,378–159,756,319, forward strandWTAPACAT2: 159,761,445–159,788,182, forward strandACAT2TCP1: 159,778,498–159,789,602, reverse strandTCP1MRPL18: 159,789,812–159,799,027, forward strandMRPL18PNLDC1: 159,800,249–159,820,704, forward strandPNLDC1MAS1: 159,830,066–159,917,447, forward strandMAS1IGF2R: 159,969,033–160,113,507, forward strandIGF2RSLC22A1: 160,121,372–160,160,590, forward strandSLC22A1SLC22A2: 160,171,061–160,277,638, reverse strandSLC22A2Diagram of TCP1: 12 exons on the reverse strand of chromosome 6Exon 11: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 12: 159,778,498–159,779,261, 764 basesExon 11: 159,779,627–159,779,790, 164 basesExon 10: 159,779,895–159,780,087, 193 basesExon 9: 159,780,443–159,780,566, 124 basesExon 8: 159,780,935–159,781,110, 176 basesExon 7: 159,783,941–159,784,067, 127 basesExon 6: 159,784,666–159,784,847, 182 basesExon 5: 159,785,386–159,785,496, 111 basesExon 4: 159,785,900–159,785,997, 98 basesExon 3: 159,787,743–159,787,871, 129 basesExon 2: 159,788,058–159,788,143, 86 basesExon 1: 159,789,405–159,789,602, 198 bases1211109876543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.4 kb of the gene's 11.1 kb; 1,671 of those bases code for the protein.

    How a genome test reads TCP1

    2

    positions in TCP1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 11.1 kb of TCP1, introns included, not only the 2.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). TCP1 gene: t-complex 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/tcp1

    Vancouver

    Dante Labs. TCP1 gene: t-complex 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tcp1

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