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Gene

ZNF462

zinc finger protein 462

Summary

Cytogenetic location
9q31.2
Coordinates
Chromosome 9: 106,863,166–107,013,634 (GRCh38)
Exons
13 exons across 150.5 kb
Protein
2,506 amino acids
Also known as
DKFZP762N2316, KIAA1803, Zfp462
MANE Select transcript
ENST00000277225.10NM_021224.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Syndromic Craniosynostosis

    • Conditions combining early skull suture closure with other features, including Apert, Crouzon, Pfeiffer, Muenke and Saethre-Chotzen syndromes, caused by genes such as FGFR2, FGFR3, FGFR1, TWIST1, TCF12 and ERF.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis allows timely surgery and monitoring of head growth, vision and hearing; milder forms such as Muenke syndrome can go unrecognised in adults, which is relevant to family planning.

How ZNF462 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where ZNF462 sits. ZNF462 and 1 gene near it on chromosome 9, from 106,438,400 to 107,438,399.Chromosome 99q31.2p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3106.6 Mb106.8 Mb107 Mb107.2 Mb107.4 MbZNF462: 106,863,166–107,013,634, forward strandZNF462RAD23B: 107,283,137–107,332,192, forward strandRAD23BDiagram of ZNF462: 13 exons on the forward strand of chromosome 9Exon 3: 36 known disease-causing sitesExon 4: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 1: 106,863,166–106,863,355, 190 basesExon 2: 106,923,354–106,923,603, 250 basesExon 3: 106,924,133–106,929,759, 5,627 basesExon 4: 106,930,525–106,930,689, 165 basesExon 5: 106,932,446–106,932,549, 104 basesExon 6: 106,935,503–106,935,621, 119 basesExon 7: 106,938,916–106,939,107, 192 basesExon 8: 106,972,005–106,972,272, 268 basesExon 9: 106,974,137–106,974,273, 137 basesExon 10: 106,984,186–106,984,409, 224 basesExon 11: 107,003,294–107,003,426, 133 basesExon 12: 107,009,545–107,009,668, 124 basesExon 13: 107,010,823–107,013,634, 2,812 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.3 kb of the gene's 150.5 kb; 7,521 of those bases code for the protein.

How a genome test reads ZNF462

45

positions in ZNF462 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 150.5 kb of ZNF462, introns included, not only the 10.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZNF462 gene: zinc finger protein 462. Retrieved 17 October 2026, from https://dantelabs.com/genes/znf462

Vancouver

Dante Labs. ZNF462 gene: zinc finger protein 462 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/znf462

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