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Gene

ZNF423

zinc finger protein 423

Summary

Cytogenetic location
16q12.1
Coordinates
Chromosome 16: 49,487,524–49,856,112 (GRCh38)
Exons
8 exons across 368.6 kb
Protein
1,292 amino acids
Inheritance
Autosomal recessive
Also known as
KIAA0760, OAZ, hOAZ, Ebfaz, Zfp104, NPHP14, JBTS19
MANE Select transcript
ENST00000563137.7NM_001379286.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Joubert Syndrome And Related Disorders

    • Joubert Syndrome

      A ciliopathy defined by a malformation of the cerebellum and brainstem (the molar tooth sign), with low muscle tone, developmental delay and abnormal eye movements, sometimes with kidney, liver or eye involvement.

      • 1 GenCC submitter rates it definitive or strong

  • Nephronophthisis and Senior-Løken Syndrome

    • NephronophthisisAutosomal recessive

      A recessively inherited kidney disease, caused by variants in NPHP1 and other cilia genes, in which progressive tubulointerstitial scarring leads to kidney failure, typically in the first three decades of life.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing allows regular kidney function monitoring, timely planning for dialysis or transplantation, and carrier testing for relatives.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ZNF423 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 16, with a bracket where ZNF423 sits. ZNF423 and 5 genes near it on chromosome 16, from 49,118,935 to 50,224,701.Chromosome 1616q12.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.349.2 Mb49.4 Mb49.6 Mb49.8 Mb50 Mb50.2 MbCBLN1: 49,277,687–49,281,879, reverse strandCBLN1C16orf78: 49,373,804–49,399,431, forward strandC16orf78ZNF423: 49,487,524–49,856,112, reverse strandZNF423CNEP1R1: 50,024,410–50,042,799, forward strandCNEP1R1HEATR3: 50,065,960–50,107,272, forward strandHEATR3TENT4B: 50,152,901–50,235,310, forward strandTENT4BDiagram of ZNF423: 8 exons on the reverse strand of chromosome 16Exon 8: 49,487,524–49,491,304, 3,781 basesExon 7: 49,523,624–49,523,739, 116 basesExon 6: 49,525,363–49,525,494, 132 basesExon 5: 49,626,170–49,626,254, 85 basesExon 4: 49,635,660–49,638,874, 3,215 basesExon 3: 49,730,771–49,730,971, 201 basesExon 2: 49,789,487–49,789,546, 60 basesExon 1: 49,855,735–49,856,112, 378 bases864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 368.6 kb; 3,879 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZNF423 gene: zinc finger protein 423. Retrieved 17 October 2026, from https://dantelabs.com/genes/znf423

Vancouver

Dante Labs. ZNF423 gene: zinc finger protein 423 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/znf423

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