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Gene

GPNMB

glycoprotein nmb

Summary

Cytogenetic location
7p15.3
Coordinates
Chromosome 7: 23,246,775–23,275,108 (GRCh38)
Exons
11 exons across 28.3 kb
Protein
560 amino acids
Inheritance
Autosomal dominant
Also known as
NMB, HGFIN
MANE Select transcript
ENST00000258733.9NM_002510.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Amyloidosis

    • Autosomal dominant

      Hereditary amyloidosis refers to a group of inherited conditions that make up one of the subtypes of amyloidosis. Hereditary amyloidosisis characterized by the deposit of an abnormal protein called amyloid in multiple organs of the body where it should not be, which causes disruption of organ tissue structure and function. In hereditary amyloidosis, amyloid deposits most often occur in tissues of the heart, kidneys, and nervous system. While symptoms of hereditary amyloidosis may appear in childhood, most individuals do not experience symptoms until adulthood. There are many types of hereditary amyloidosis associated with different gene mutations and abnormal proteins. The most common type of hereditary amyloidosis is transthyretin amyloidosis (ATTR), a condition in which the amyloid deposits are most often made up of the transthyretin protein which is made in the liver. Other examplesof hereditary amyloidosis include, but are not limited to, apolipoprotein AI amyloidosis (A ApoAI), gelsolin amyloidosis (A Gel), lysozyme amyloidosis (A Lys), cystatin C amyloidosis (A Cys), fibrinogen Aα-chain amyloidosis (A Fib), and apolipoprotein AII amyloidosis (A ApoAII).

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Tafamidis (kinetic stabilizer), patisiran (RNAi), vutrisiran (RNAi), inotersen (antisense), liver transplantation

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How GPNMB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where GPNMB sits. GPNMB and 10 genes near it on chromosome 7, from 22,760,942 to 23,760,941.Chromosome 77p15.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.322.8 Mb23 Mb23.2 Mb23.4 Mb23.6 MbTOMM7: 22,812,628–22,822,891, reverse strandTOMM7HYCC1: 22,889,371–23,014,148, reverse strandHYCC1KLHL7: 23,105,729–23,177,914, forward strandKLHL7NUP42: 23,181,804–23,201,011, forward strandNUP42GPNMB: 23,246,775–23,275,108, forward strandGPNMBMALSU1: 23,298,739–23,311,729, forward strandMALSU1IGF2BP3: 23,308,571–23,470,833, reverse strandIGF2BP3TRA2A: 23,504,780–23,532,041, reverse strandTRA2ACCDC126: 23,597,374–23,644,714, forward strandCCDC126FAM221A: 23,680,114–23,706,228, forward strandFAM221ASTK31: 23,710,203–23,832,513, forward strandSTK31Diagram of GPNMB: 11 exons on the forward strand of chromosome 7Exon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 1: 23,246,775–23,246,927, 153 basesExon 2: 23,253,307–23,253,459, 153 basesExon 3: 23,254,169–23,254,312, 144 basesExon 4: 23,256,892–23,257,065, 174 basesExon 5: 23,259,980–23,260,138, 159 basesExon 6: 23,260,456–23,260,773, 318 basesExon 7: 23,266,517–23,266,615, 99 basesExon 8: 23,267,886–23,267,988, 103 basesExon 9: 23,269,967–23,270,175, 209 basesExon 10: 23,273,521–23,273,614, 94 basesExon 11: 23,274,065–23,275,108, 1,044 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 28.3 kb; 1,683 of those bases code for the protein.

How a genome test reads GPNMB

11

positions in GPNMB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28.3 kb of GPNMB, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPNMB gene: glycoprotein nmb. Retrieved 17 October 2026, from https://dantelabs.com/genes/gpnmb

Vancouver

Dante Labs. GPNMB gene: glycoprotein nmb [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gpnmb

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