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Gene

FOSL2

FOS like 2, AP-1 transcription factor subunit

Summary

Cytogenetic location
2p23.2
Coordinates
Chromosome 2: 28,392,858–28,417,317 (GRCh38)
Exons
4 exons across 24.5 kb
Protein
326 amino acids
Also known as
FRA2, FLJ23306
MANE Select transcript
ENST00000264716.9NM_005253.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How FOSL2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 2, with a bracket where FOSL2 sits. FOSL2 and 7 genes near it on chromosome 2, from 27,905,088 to 28,905,087.Chromosome 22p23.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.328 Mb28.2 Mb28.4 Mb28.6 Mb28.8 Mb: 27,771,739–27,988,087, forward strandBABAM2: 27,888,667–28,339,184, forward strandBABAM2FOSL2: 28,392,858–28,417,317, forward strandFOSL2PLB1: 28,457,145–28,645,904, forward strandPLB1PPP1CB: 28,751,079–28,802,964, forward strandPPP1CBSPDYA: 28,782,517–28,850,611, forward strandSPDYATRMT61B: 28,798,308–28,870,392, reverse strandTRMT61BWDR43: 28,894,611–28,948,926, forward strandWDR43Diagram of FOSL2: 4 exons on the forward strand of chromosome 2Exon 4: 2 known disease-causing sitesExon 1: 28,392,858–28,393,822, 965 basesExon 2: 28,404,107–28,404,358, 252 basesExon 3: 28,408,759–28,408,866, 108 basesExon 4: 28,411,930–28,417,317, 5,388 bases12345′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.7 kb of the gene's 24.5 kb; 981 of those bases code for the protein.

    How a genome test reads FOSL2

    2

    positions in FOSL2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 24.5 kb of FOSL2, introns included, not only the 6.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FOSL2 gene: FOS like 2, AP-1 transcription factor subunit. Retrieved 16 October 2026, from https://dantelabs.com/genes/fosl2

    Vancouver

    Dante Labs. FOSL2 gene: FOS like 2, AP-1 transcription factor subunit [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fosl2

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