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Gene

ZNF341

zinc finger protein 341

Summary

Cytogenetic location
20q11.22
Coordinates
Chromosome 20: 33,731,996–33,792,269 (GRCh38)
Exons
15 exons across 60.3 kb
Protein
854 amino acids
Also known as
dJ553F4.3
MANE Select transcript
ENST00000375200.6NM_001282933.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hyper-IgE Syndrome

    • A condition that is characterized by elevated serum IgE, dermatitis, and respiratory infections.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How ZNF341 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where ZNF341 sits. ZNF341 and 13 genes near it on chromosome 20, from 33,262,133 to 34,262,132.Chromosome 2020q11.22p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3333.4 Mb33.6 Mb33.8 Mb34 Mb34.2 MbBPIFB1: 33,273,480–33,310,382, forward strandBPIFB1CDK5RAP1: 33,348,588–33,401,561, reverse strandCDK5RAP1SNTA1: 33,407,955–33,443,897, reverse strandSNTA1CBFA2T2: 33,490,060–33,650,036, forward strandCBFA2T2NECAB3: 33,657,087–33,674,473, reverse strandNECAB3C20orf144: 33,662,327–33,665,619, forward strandACTL10: 33,666,943–33,668,525, forward strandACTL10E2F1: 33,675,477–33,686,426, reverse strandE2F1PXMP4: 33,702,758–33,720,412, reverse strandPXMP4ZNF341: 33,731,996–33,792,269, forward strandZNF341CHMP4B: 33,811,253–33,854,366, forward strandCHMP4BRALY: 33,993,632–34,108,308, forward strandRALYEIF2S2: 34,088,309–34,112,284, reverse strandEIF2S2ASIP: 34,194,569–34,269,346, forward strandASIPDiagram of ZNF341: 15 exons on the forward strand of chromosome 20Exon 2: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 1: 33,731,996–33,732,052, 57 basesExon 2: 33,740,902–33,741,012, 111 basesExon 3: 33,745,103–33,745,299, 197 basesExon 4: 33,748,923–33,749,072, 150 basesExon 5: 33,753,172–33,753,423, 252 basesExon 6: 33,757,148–33,757,343, 196 basesExon 7: 33,758,716–33,758,806, 91 basesExon 8: 33,761,862–33,762,055, 194 basesExon 9: 33,766,851–33,767,041, 191 basesExon 10: 33,770,084–33,770,292, 209 basesExon 11: 33,781,291–33,781,387, 97 basesExon 12: 33,783,732–33,783,864, 133 basesExon 13: 33,788,863–33,788,974, 112 basesExon 14: 33,789,518–33,789,588, 71 basesExon 15: 33,790,988–33,792,269, 1,282 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 60.3 kb; 2,565 of those bases code for the protein.

How a genome test reads ZNF341

7

positions in ZNF341 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 60.3 kb of ZNF341, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZNF341 gene: zinc finger protein 341. Retrieved 16 October 2026, from https://dantelabs.com/genes/znf341

Vancouver

Dante Labs. ZNF341 gene: zinc finger protein 341 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/znf341

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