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Gene

FLG

filaggrin

Summary

Cytogenetic location
1q21.3
Coordinates
Chromosome 1: 152,302,165–152,325,239 (GRCh38)
Exons
3 exons across 23.1 kb
Protein
4,061 amino acids
Also known as
FLG1, FLG-1
MANE Select transcript
ENST00000368799.2NM_002016.2
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Ichthyosis Vulgaris

    • Ichthyosis vulgaris (filaggrin deficiency)

      Dry, fine scaling, especially on the shins, with increased palm creases; one FLG variant gives a milder effect and two give a stronger one.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Regular emollients and skin-barrier care help, and carriers may benefit from extra attention to eczema and skin irritants.

How FLG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where FLG sits. FLG and 31 genes near it on chromosome 1, from 151,813,702 to 152,813,701.Chromosome 11q21.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44152 Mb152.2 Mb152.4 Mb152.6 Mb152.8 MbRORC: 151,806,021–151,831,845, reverse strandRORCC2CD4D: 151,837,818–151,840,557, reverse strandC2CD4DTHEM5: 151,847,101–151,853,712, reverse strandTHEM5THEM4: 151,870,866–151,909,879, reverse strandTHEM4S100A10: 151,981,697–151,993,891, reverse strandS100A10S100A11: 152,032,504–152,047,907, reverse strandS100A11TCHHL1: 152,084,141–152,089,064, reverse strandTCHHL1TCHH: 152,106,317–152,115,444, reverse strandTCHHRPTN: 152,153,595–152,159,228, reverse strandRPTNHRNR: 152,212,076–152,224,193, reverse strandHRNRFLG: 152,302,165–152,325,239, reverse strandFLGFLG2: 152,348,735–152,360,006, reverse strandFLG2CRNN: 152,409,242–152,414,279, reverse strandCRNNLCE5A: 152,510,803–152,512,177, forward strandLCE5ACRCT1: 152,514,482–152,516,008, forward strandCRCT1LCE3E: 152,565,654–152,566,780, reverse strandLCE3ELCE3D: 152,579,381–152,580,516, reverse strandLCE3DLCE3C: 152,600,234–152,601,086, forward strandLCE3CLCE3B: 152,613,811–152,614,098, forward strandLCE3BLCE3A: 152,622,834–152,623,103, reverse strandLCE3ALCE2D: 152,658,824–152,664,659, forward strandLCE2DLCE2C: 152,675,279–152,676,569, forward strandLCE2CLCE2B: 152,686,123–152,687,397, forward strandLCE2BLCE2A: 152,698,345–152,699,442, forward strandLCE2ALCE4A: 152,708,160–152,709,434, forward strandKPLCE: 152,719,522–152,720,470, forward strandKPLCEKPRP: 152,758,025–152,762,056, forward strandKPRPLCE1F: 152,775,140–152,777,024, forward strandLCE1FLCE1E: 152,786,214–152,788,426, forward strandLCE1ELCE1D: 152,796,721–152,798,181, forward strandLCE1DLCE1C: 152,804,832–152,806,651, reverse strandLCE1B: 152,811,971–152,813,108, forward strandDiagram of FLG: 3 exons on the reverse strand of chromosome 1Exon 3: 118 known disease-causing sitesExon 2: 1 known disease-causing siteExon 3: 152,302,165–152,314,747, 12,583 basesExon 2: 152,315,319–152,315,477, 159 basesExon 1: 152,325,189–152,325,239, 51 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.8 kb of the gene's 23.1 kb; 12,186 of those bases code for the protein.

How a genome test reads FLG

120

positions in FLG where ClinVar classes a change as pathogenic or likely pathogenic

110 of them (92%) fall in regions short reads find hard.

  • Low mappability (48 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (110 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 23.1 kb of FLG, introns included, not only the 12.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FLG gene: filaggrin. Retrieved 16 October 2026, from https://dantelabs.com/genes/flg

Vancouver

Dante Labs. FLG gene: filaggrin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/flg

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