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Gene

TRPM1

transient receptor potential cation channel subfamily M member 1

Summary

Cytogenetic location
15q13.3
Coordinates
Chromosome 15: 31,001,065–31,101,725 (GRCh38)
Exons
28 exons across 100.7 kb
Protein
1,625 amino acids
Also known as
LTRPC1, CSNB1C
Previous symbols
MLSN1
MANE Select transcript
ENST00000256552.11NM_001252024.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Stationary Night Blindness

    • A group of mostly non-progressive retinal conditions, including Oguchi disease, caused by changes in genes such as NYX, CACNA1F, TRPM1, GRM6, GPR179 and SAG, often with nystagmus or short-sightedness.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis explains the symptoms, helps distinguish the condition from progressive retinal diseases and informs family counselling.

How TRPM1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where TRPM1 sits. TRPM1 and 8 genes near it on chromosome 15, from 30,551,395 to 31,551,394.Chromosome 1515q13.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.330.6 Mb30.8 Mb31 Mb31.2 Mb31.4 MbGOLGA8Q: 30,552,050–30,565,684, forward strandGOLGA8QGOLGA8H: 30,604,028–30,617,752, forward strandGOLGA8HARHGAP11B: 30,624,494–30,649,529, forward strandARHGAP11B: 30,624,548–30,773,002, forward strandFAN1: 30,890,559–30,946,209, forward strandFAN1MTMR10: 30,918,719–30,991,979, reverse strandMTMR10TRPM1: 31,001,065–31,101,725, reverse strandTRPM1KLF13: 31,326,687–31,435,665, forward strandKLF13OTUD7A: 31,475,398–31,870,789, reverse strandOTUD7ADiagram of TRPM1: 28 exons on the reverse strand of chromosome 15Exon 28: 1 known disease-causing siteExon 27: 2 known disease-causing sitesExon 26: 1 known disease-causing siteExon 23: 4 known disease-causing sitesExon 22: 2 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 20: 1 known disease-causing siteExon 19: 2 known disease-causing sitesExon 18: 2 known disease-causing sitesExon 17: 3 known disease-causing sitesExon 11: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 28: 31,001,065–31,003,070, 2,006 basesExon 27: 31,026,139–31,026,271, 133 basesExon 26: 31,026,915–31,027,117, 203 basesExon 25: 31,028,332–31,028,476, 145 basesExon 24: 31,029,371–31,029,391, 21 basesExon 23: 31,030,983–31,031,157, 175 basesExon 22: 31,032,689–31,032,940, 252 basesExon 21: 31,035,546–31,035,674, 129 basesExon 20: 31,037,711–31,037,842, 132 basesExon 19: 31,038,044–31,038,166, 123 basesExon 18: 31,040,118–31,040,346, 229 basesExon 17: 31,041,951–31,042,243, 293 basesExon 16: 31,046,204–31,046,233, 30 basesExon 15: 31,047,111–31,047,251, 141 basesExon 14: 31,047,889–31,047,939, 51 basesExon 13: 31,049,375–31,049,509, 135 basesExon 12: 31,050,409–31,050,582, 174 basesExon 11: 31,060,544–31,060,644, 101 basesExon 10: 31,061,442–31,061,514, 73 basesExon 9: 31,062,579–31,062,702, 124 basesExon 8: 31,063,118–31,063,292, 175 basesExon 7: 31,066,076–31,066,247, 172 basesExon 6: 31,067,063–31,067,187, 125 basesExon 5: 31,067,879–31,068,092, 214 basesExon 4: 31,070,031–31,070,226, 196 basesExon 3: 31,076,905–31,076,984, 80 basesExon 2: 31,081,353–31,081,438, 86 basesExon 1: 31,101,657–31,101,725, 69 bases2825201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 100.7 kb; 4,878 of those bases code for the protein.

How a genome test reads TRPM1

37

positions in TRPM1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 100.7 kb of TRPM1, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRPM1 gene: transient receptor potential cation channel subfamily M member 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/trpm1

Vancouver

Dante Labs. TRPM1 gene: transient receptor potential cation channel subfamily M member 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trpm1

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