Gene
RNF113A
ring finger protein 113A
- HGNC 12974↗(opens in a new tab)
- Ensembl gene ENSG00000125352↗(opens in a new tab)
- NCBI Gene 7737↗(opens in a new tab)
Summary
- Cytogenetic location
- Xq24
- Coordinates
- Chromosome X: 119,870,475–119,871,733 (GRCh38)
- Exons
- 1 exon across 1.3 kb
- Protein
- 343 amino acids
- Also known as
- RNF113, Cwc24
- Previous symbols
- ZNF183
- MANE Select transcript
- ENST00000371442.4NM_006978.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads RNF113A yet. The test sequences your whole genome, so your data includes it all the same.
How RNF113A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.3 kb of the gene's 1.3 kb; 1,032 of those bases code for the protein.
How a genome test reads RNF113A
1
position in RNF113A where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 1.3 kb of RNF113A, introns included, not only the 1.3 kb of exons.
Traits linked to RNF113A
The Human Phenotype Ontology lists these as features of the rare conditions RNF113A can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Delayed speech and language development
- Inability to coordinate movements when walking
- IQ less than 20
- Small cerebellum
- Wide based walk
- Abnormal pyramidal sign
- Cerebral dysmyelination
- Decrease in size of the outer layer of the brain due to loss of brain cells
Show 14 more traits
- Decreased reflex response
- Difficulty articulating speech
- Diffuse cerebellar atrophy
- Generalized hyperreflexia
- Generalized-onset seizure
- Global developmental delay
- Intention tremor
- Paraplegia/paraparesis
- Partial agenesis of the corpus callosum
- Peripheral neuropathy
- Periventricular leukomalacia
- Poor social interactions
- Ventriculomegaly
- Generalized brain degeneration
Abnormality of the musculoskeletal system
- Absent fat below the skin
- Delayed bone maturation
- Generalized decreased muscle tone
- Increased bone mineral density
- Involuntary muscle stiffness, contraction, or spasm
- Joint dislocation
- Multiple joint contractures
- Osteopenia
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). RNF113A gene: ring finger protein 113A. Retrieved 17 October 2026, from https://dantelabs.com/genes/rnf113a
Dante Labs. RNF113A gene: ring finger protein 113A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rnf113a
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