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Gene

TRHR

thyrotropin releasing hormone receptor

Summary

Cytogenetic location
8q23.1
Coordinates
Chromosome 8: 109,086,585–109,121,565 (GRCh38)
Exons
3 exons across 35 kb
Protein
398 amino acids
MANE Select transcript
ENST00000518632.2NM_003301.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Hypothyroidism

    • A thyroid hormone deficiency present from birth.

      • 2 GenCC submitters rate it definitive or strong

  • Thyroid Cancer

    • Hypothyroidism

      Abnormally low levels of thyroid hormone.

      • 2 GenCC submitters rate it definitive or strong
    • Thyroid Gland Disorder

      A disease involving the thyroid gland.

      • 2 GenCC submitters rate it definitive or strong

How TRHR is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where TRHR sits. TRHR and 7 genes near it on chromosome 8, from 108,604,075 to 109,604,074.Chromosome 88q23.1p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3108.8 Mb109 Mb109.2 Mb109.4 Mb109.6 MbTMEM74: 108,606,850–108,787,624, reverse strandTMEM74TRHR: 109,086,585–109,121,565, forward strandTRHRNUDCD1: 109,138,683–109,334,493, reverse strandNUDCD1ENY2: 109,333,555–109,345,954, forward strandENY2PKHD1L1: 109,362,429–109,537,207, forward strandPKHD1L1EBAG9: 109,539,621–109,570,072, forward strandEBAG9EBAG9UORF: 109,539,726–109,539,800, forward strandEBAG9UORFSYBU: 109,573,978–109,691,799, reverse strandSYBUDiagram of TRHR: 3 exons on the forward strand of chromosome 8Exon 2: 5 known disease-causing sitesExon 3: 1 known disease-causing siteExon 1: 109,086,585–109,086,883, 299 basesExon 2: 109,087,425–109,088,301, 877 basesExon 3: 109,119,048–109,121,565, 2,518 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 35 kb; 1,197 of those bases code for the protein.

How a genome test reads TRHR

6

positions in TRHR where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 35 kb of TRHR, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRHR gene: thyrotropin releasing hormone receptor. Retrieved 17 October 2026, from https://dantelabs.com/genes/trhr

Vancouver

Dante Labs. TRHR gene: thyrotropin releasing hormone receptor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trhr

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