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Gene

TINF2

TERF1 interacting nuclear factor 2

Summary

Cytogenetic location
14q12
Coordinates
Chromosome 14: 24,239,643–24,242,623 (GRCh38)
Exons
9 exons across 3 kb
Protein
451 amino acids
Also known as
TIN2
MANE Select transcript
ENST00000267415.12NM_001099274.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Dyskeratosis Congenita

    • Dyskeratosis congenita (DC) is a rare ectodermal dysplasia that often presents with the classic triad of nail dysplasia, skin pigmentary changes, and oral leukoplakia associated with a high risk of bone marrow failure (BMF) and cancer.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How TINF2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where TINF2 sits. TINF2 and 44 genes near it on chromosome 14, from 23,741,133 to 24,741,132.Chromosome 1414q12p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3323.8 Mb24 Mb24.2 Mb24.4 Mb24.6 MbDHRS4: 23,953,713–23,969,279, forward strandDHRS4DHRS4L2: 23,969,874–24,006,408, forward strandDHRS4L2CARMIL3: 24,051,387–24,069,734, forward strandCARMIL3CPNE6: 24,070,837–24,078,100, forward strandCPNE6NRL: 24,078,662–24,115,026, reverse strandNRLPCK2: 24,094,053–24,110,598, forward strandPCK2DCAF11: 24,114,010–24,125,615, forward strand: 24,120,956–24,131,829, forward strandFITM1: 24,130,659–24,132,849, forward strandPSME1: 24,136,142–24,138,967, forward strandEMC9: 24,138,958–24,142,023, reverse strandPSME2: 24,143,360–24,147,570, reverse strandRNF31: 24,146,683–24,160,660, forward strandRNF31: 24,147,548–24,166,452, forward strandIRF9: 24,161,101–24,168,043, forward strandREC8: 24,171,853–24,180,923, forward strandREC8IPO4: 24,180,043–24,188,990, reverse strand: 24,180,395–24,190,416, reverse strandTM9SF1: 24,189,140–24,196,287, reverse strand: 24,189,157–24,213,473, reverse strandTSSK4: 24,205,696–24,208,362, forward strandCHMP4A: 24,209,581–24,213,830, reverse strandMDP1: 24,213,939–24,216,070, reverse strandNEDD8-MDP1: 24,213,955–24,232,352, reverse strandNEDD8: 24,216,802–24,232,539, reverse strandNEDD8GMPR2: 24,232,211–24,239,246, forward strandGMPR2TINF2: 24,239,643–24,242,623, reverse strandTINF2TGM1: 24,249,114–24,264,432, reverse strandTGM1RABGGTA: 24,265,468–24,271,620, reverse strandDHRS1: 24,290,594–24,300,136, reverse strandDHRS1NOP9: 24,299,825–24,309,124, forward strandNOP9CIDEB: 24,305,187–24,311,454, reverse strandCIDEBLTB4R2: 24,305,734–24,312,053, forward strandLTB4R2LTB4R: 24,311,188–24,318,036, forward strandADCY4: 24,318,091–24,335,208, reverse strandRIPK3: 24,336,025–24,340,022, reverse strandNFATC4: 24,365,673–24,379,613, forward strandNFATC4NYNRIN: 24,398,861–24,419,304, forward strandNYNRINKHNYN: 24,423,052–24,441,846, forward strandKHNYNCBLN3: 24,423,886–24,430,972, reverse strandCBLN3SDR39U1: 24,439,651–24,442,905, reverse strandSDR39U1CMA1: 24,505,353–24,508,271, reverse strandCMA1CTSG: 24,573,518–24,576,250, reverse strandCTSGGZMH: 24,606,480–24,609,821, reverse strandGZMHGZMB: 24,630,954–24,634,277, reverse strandGZMBDiagram of TINF2: 9 exons on the reverse strand of chromosome 14Exon 7: 1 known disease-causing siteExon 6: 9 known disease-causing sitesExon 1: 1 known disease-causing siteExon 9: 24,239,643–24,239,931, 289 basesExon 8: 24,240,064–24,240,155, 92 basesExon 7: 24,240,263–24,240,330, 68 basesExon 6: 24,240,419–24,240,875, 457 basesExon 5: 24,241,020–24,241,116, 97 basesExon 4: 24,241,204–24,241,311, 108 basesExon 3: 24,241,675–24,241,776, 102 basesExon 2: 24,241,890–24,241,994, 105 basesExon 1: 24,242,141–24,242,623, 483 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 3 kb; 1,356 of those bases code for the protein.

Sequencing TINF2

11

positions in TINF2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3 kb of TINF2, introns included, not only the 1.8 kb of exons.

Genes linked to the same conditions

Traits linked to TINF2

The Human Phenotype Ontology lists these as features of the rare conditions TINF2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). TINF2 gene: TERF1 interacting nuclear factor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tinf2

Vancouver

Dante Labs. TINF2 gene: TERF1 interacting nuclear factor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tinf2

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