Gene
CDKN2B
cyclin dependent kinase inhibitor 2B
- HGNC 1788(opens in a new tab)
- Ensembl gene ENSG00000147883(opens in a new tab)
- NCBI Gene 1030(opens in a new tab)
Summary
- Cytogenetic location
- 9p21.3
- Coordinates
- Chromosome 9: 22,002,903–22,009,305 (GRCh38)
- Exons
- 2 exons across 6.4 kb
- Protein
- 138 amino acids
- Also known as
- P15, MTS2, INK4B, TP15, CDK4I, p15INK4b
- MANE Select transcript
- ENST00000276925.7NM_004936.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How CDKN2B is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.9 kb of the gene's 6.4 kb; 417 of those bases code for the protein.
Traits linked to CDKN2B
The Human Phenotype Ontology lists these as features of the rare conditions CDKN2B can cause. Each trait's page lists the other genes linked to it.
Abnormality of the endocrine system
- Enlarged parathyroid glands
- Primary hyperparathyroidism
- Adrenocortical abnormality
- Elevated gastrin in the blood
- Noncancerous tumor in pituitary gland
- Pituitary prolactin cell adenoma
- Abnormal circulating aldosterone
- Adrenocortical carcinoma
Show 17 more traits
- Carcinoid tumor
- Enlarged thyroid gland in neck
- Growth hormone excess
- Increased circulating cortisol level
- Pancreatic endocrine tumor
- Pituitary growth hormone cell adenoma
- Primary hypercortisolism
- Thyroid carcinoma
- Glucagonoma
- Increased serum serotonin
- Parathyroid carcinoma
- Pheochromocytoma
- Pituitary corticotropic cell adenoma
- Pituitary gonadotropic cell adenoma
- Pituitary null cell adenoma
- Pituitary thyrotropic cell adenoma
- Pulmonary carcinoid tumor
Abnormality of the digestive system
- Abdominal pain
- Acid reflux
- Cancer of the pancreas
- Diarrhea
- Sore in the lining of gastrointestinal tract
- Zollinger-Ellison syndrome
- Anorexia
- Constipation
Show 6 more traits
Abnormality of the nervous system
- Abnormality of extrapyramidal motor function
- Confusion
- Cranial nerve compression
- Decreased vigilance
- Depression
- Headache
- Lethargy
- Noncancerous growth of membranes covering brain
Show 4 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). CDKN2B gene: cyclin dependent kinase inhibitor 2B. Retrieved 16 October 2026, from https://dantelabs.com/genes/cdkn2b
Dante Labs. CDKN2B gene: cyclin dependent kinase inhibitor 2B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cdkn2b
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