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Gene

CLDN10

claudin 10

Summary

Cytogenetic location
13q32.1
Coordinates
Chromosome 13: 95,552,720–95,579,759 (GRCh38)
Exons
5 exons across 27 kb
Protein
228 amino acids
Inheritance
Autosomal recessive
Also known as
OSP-L, CPETRL3
MANE Select transcript
ENST00000299339.3NM_006984.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Hypomagnesemia

    • HELIX SyndromeAutosomal recessive

      A recessive CLDN10 disorder with reduced sweating, dry eyes and mouth, and kidney salt wasting with high blood magnesium.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing explains the electrolyte findings and guides supportive care.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CLDN10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where CLDN10 sits. CLDN10 and 4 genes near it on chromosome 13, from 95,066,240 to 96,066,239.Chromosome 1313q32.1p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3495.2 Mb95.4 Mb95.6 Mb95.8 Mb96 MbABCC4: 95,019,831–95,301,822, reverse strandABCC4CLDN10: 95,552,720–95,579,759, forward strandCLDN10DZIP1: 95,578,202–95,644,740, reverse strandDZIP1DNAJC3: 95,676,600–95,794,988, forward strandDNAJC3UGGT2: 95,801,580–96,053,482, reverse strandUGGT2Diagram of CLDN10: 5 exons on the forward strand of chromosome 13Exon 1: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 95,552,720–95,552,973, 254 basesExon 2: 95,560,132–95,560,293, 162 basesExon 3: 95,560,382–95,560,463, 82 basesExon 4: 95,577,231–95,577,338, 108 basesExon 5: 95,577,900–95,579,759, 1,860 bases12455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 27 kb; 687 of those bases code for the protein.

How a genome test reads CLDN10

3

positions in CLDN10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 27 kb of CLDN10, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CLDN10 gene: claudin 10. Retrieved 16 October 2026, from https://dantelabs.com/genes/cldn10

Vancouver

Dante Labs. CLDN10 gene: claudin 10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cldn10

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