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Gene

TG

thyroglobulin

Summary

Cytogenetic location
8q24.22
Coordinates
Chromosome 8: 132,866,958–133,134,899 (GRCh38)
Exons
48 exons across 267.9 kb
Protein
2,768 amino acids
Also known as
TGN, AITD3
MANE Select transcript
ENST00000220616.9NM_003235.5
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Hypothyroidism

    • A thyroid hormone deficiency present from birth.

      • 2 GenCC submitters rate it definitive or strong

  • Thyroid Cancer

    • Inherited Thyroid Metabolism Disease

      An inherited metabolic disease that is has its basis in the disruption of thyroid hormone metabolic process.

      • 2 GenCC submitters rate it definitive or strong
    • Hypothyroidism

      Abnormally low levels of thyroid hormone.

      • 2 GenCC submitters rate it definitive or strong
    • Thyroid Gland Disorder

      A disease involving the thyroid gland.

      • 2 GenCC submitters rate it definitive or strong

How TG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where TG sits. TG and 7 genes near it on chromosome 8, from 132,500,929 to 133,500,928.Chromosome 88q24.22p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3132.6 Mb132.8 Mb133 Mb133.2 Mb133.4 MbDNAAF11: 132,570,133–132,675,622, reverse strandDNAAF11TMEM71: 132,685,007–132,760,712, reverse strandTMEM71PHF20L1: 132,775,311–132,850,003, forward strandPHF20L1TG: 132,866,958–133,134,899, forward strandTGSLA: 133,035,385–133,129,216, reverse strandSLACCN4: 133,190,866–133,231,690, forward strandCCN4NDRG1: 133,237,171–133,302,022, reverse strandNDRG1ST3GAL1: 133,454,848–133,572,518, reverse strandST3GAL1Diagram of TG: 48 exons on the forward strand of chromosome 8Exon 2: 1 known disease-causing siteExon 3: 3 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 9: 7 known disease-causing sitesExon 10: 5 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 20: 2 known disease-causing sitesExon 21: 1 known disease-causing siteExon 22: 3 known disease-causing sitesExon 26: 2 known disease-causing sitesExon 27: 2 known disease-causing sitesExon 34: 1 known disease-causing siteExon 36: 2 known disease-causing sitesExon 37: 1 known disease-causing siteExon 38: 4 known disease-causing sitesExon 39: 1 known disease-causing siteExon 40: 1 known disease-causing siteExon 41: 1 known disease-causing siteExon 42: 1 known disease-causing siteExon 44: 1 known disease-causing siteExon 45: 1 known disease-causing siteExon 46: 1 known disease-causing siteExon 47: 1 known disease-causing siteExon 1: 132,866,958–132,867,067, 110 basesExon 2: 132,868,115–132,868,223, 109 basesExon 3: 132,869,729–132,869,826, 98 basesExon 4: 132,871,348–132,871,551, 204 basesExon 5: 132,873,062–132,873,221, 160 basesExon 6: 132,881,863–132,881,969, 107 basesExon 7: 132,882,469–132,882,612, 144 basesExon 8: 132,882,814–132,882,999, 186 basesExon 9: 132,886,448–132,887,548, 1,101 basesExon 10: 132,887,984–132,888,568, 585 basesExon 11: 132,893,690–132,893,929, 240 basesExon 12: 132,897,649–132,897,786, 138 basesExon 13: 132,898,169–132,898,246, 78 basesExon 14: 132,898,798–132,898,910, 113 basesExon 15: 132,900,237–132,900,339, 103 basesExon 16: 132,901,353–132,901,553, 201 basesExon 17: 132,906,688–132,906,900, 213 basesExon 18: 132,908,186–132,908,340, 155 basesExon 19: 132,911,377–132,911,533, 157 basesExon 20: 132,913,047–132,913,265, 219 basesExon 21: 132,919,376–132,919,525, 150 basesExon 22: 132,923,338–132,923,508, 171 basesExon 23: 132,929,076–132,929,192, 117 basesExon 24: 132,933,561–132,933,676, 116 basesExon 25: 132,935,756–132,935,864, 109 basesExon 26: 132,941,351–132,941,542, 192 basesExon 27: 132,948,776–132,948,943, 168 basesExon 28: 132,961,008–132,961,073, 66 basesExon 29: 132,962,994–132,963,074, 81 basesExon 30: 132,966,560–132,966,697, 138 basesExon 31: 132,967,794–132,967,970, 177 basesExon 32: 132,969,458–132,969,569, 112 basesExon 33: 132,971,794–132,971,873, 80 basesExon 34: 132,972,598–132,972,741, 144 basesExon 35: 132,983,350–132,983,412, 63 basesExon 36: 133,011,901–133,012,035, 135 basesExon 37: 133,013,600–133,013,764, 165 basesExon 38: 133,017,778–133,017,997, 220 basesExon 39: 133,019,602–133,019,695, 94 basesExon 40: 133,021,991–133,022,150, 160 basesExon 41: 133,029,821–133,030,023, 203 basesExon 42: 133,095,044–133,095,208, 165 basesExon 43: 133,096,206–133,096,373, 168 basesExon 44: 133,113,422–133,113,603, 182 basesExon 45: 133,116,609–133,116,716, 108 basesExon 46: 133,131,812–133,131,946, 135 basesExon 47: 133,133,470–133,133,660, 191 basesExon 48: 133,134,676–133,134,899, 224 bases151015202530354045485′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.5 kb of the gene's 267.9 kb; 8,307 of those bases code for the protein.

How a genome test reads TG

79

positions in TG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 267.9 kb of TG, introns included, not only the 8.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TG gene: thyroglobulin. Retrieved 16 October 2026, from https://dantelabs.com/genes/tg

Vancouver

Dante Labs. TG gene: thyroglobulin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tg

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