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Gene

CAST

calpastatin

Summary

Cytogenetic location
5q15
Coordinates
Chromosome 5: 96,662,376–96,774,683 (GRCh38)
Exons
32 exons across 112.3 kb
Protein
791 amino acids
Previous symbols
MIR583HG
MANE Select transcript
ENST00000675179.1NM_001750.7
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads CAST yet. The test sequences your whole genome, so your data includes it all the same.

How CAST is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where CAST sits. CAST and 6 genes near it on chromosome 5, from 96,218,530 to 97,218,529.Chromosome 55q15p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.396.4 Mb96.6 Mb96.8 Mb97 Mb97.2 MbPCSK1: 96,390,333–96,434,143, reverse strandPCSK1CAST: 96,662,376–96,774,683, forward strandCASTERAP1: 96,759,649–96,808,177, reverse strandERAP1ERAP2: 96,875,979–96,919,703, forward strandERAP2LNPEP: 96,934,807–97,037,513, forward strandLNPEPLIX1: 97,091,867–97,142,846, reverse strandLIX1RIOK2: 97,160,867–97,183,297, reverse strandRIOK2Diagram of CAST: 32 exons on the forward strand of chromosome 5Exon 5: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 1: 96,662,376–96,662,497, 122 basesExon 2: 96,675,539–96,675,601, 63 basesExon 3: 96,695,836–96,695,907, 72 basesExon 4: 96,722,639–96,722,698, 60 basesExon 5: 96,726,794–96,726,859, 66 basesExon 6: 96,727,489–96,727,530, 42 basesExon 7: 96,729,153–96,729,209, 57 basesExon 8: 96,729,612–96,729,725, 114 basesExon 9: 96,730,780–96,730,860, 81 basesExon 10: 96,736,172–96,736,240, 69 basesExon 11: 96,737,849–96,737,947, 99 basesExon 12: 96,740,038–96,740,118, 81 basesExon 13: 96,740,745–96,740,783, 39 basesExon 14: 96,741,266–96,741,358, 93 basesExon 15: 96,741,494–96,741,580, 87 basesExon 16: 96,742,655–96,742,756, 102 basesExon 17: 96,746,342–96,746,425, 84 basesExon 18: 96,747,345–96,747,392, 48 basesExon 19: 96,748,518–96,748,613, 96 basesExon 20: 96,750,587–96,750,682, 96 basesExon 21: 96,754,060–96,754,161, 102 basesExon 22: 96,754,658–96,754,741, 84 basesExon 23: 96,757,444–96,757,494, 51 basesExon 24: 96,757,583–96,757,654, 72 basesExon 25: 96,762,274–96,762,372, 99 basesExon 26: 96,765,221–96,765,325, 105 basesExon 27: 96,766,053–96,766,145, 93 basesExon 28: 96,767,438–96,767,482, 45 basesExon 29: 96,767,907–96,767,999, 93 basesExon 30: 96,770,531–96,770,602, 72 basesExon 31: 96,771,644–96,771,702, 59 basesExon 32: 96,772,640–96,774,683, 2,044 bases151015202530325′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 112.3 kb; 2,376 of those bases code for the protein.

Sequencing CAST

5

positions in CAST where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 112.3 kb of CAST, introns included, not only the 4.5 kb of exons.

Traits linked to CAST

The Human Phenotype Ontology lists these as features of the rare conditions CAST can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CAST gene: calpastatin. Retrieved 17 October 2026, from https://dantelabs.com/genes/cast

Vancouver

Dante Labs. CAST gene: calpastatin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cast

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