Skip to content
Use your HSA or FSA funds

Gene

STS

steroid sulfatase

Summary

Cytogenetic location
Xp22.31
Coordinates
Chromosome X: 7,147,712–7,354,641 (GRCh38)
Exons
11 exons across 206.9 kb
Protein
578 amino acids
Inheritance
X-linked recessive
Also known as
ARSC
Previous symbols
ARSC1
MANE Select transcript
ENST00000674429.1NM_001320752.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Ichthyoses

    • X-linked ichthyosisX-linked recessive

      Steroid sulfatase deficiency causing dark, adherent scales mainly in males; female carriers are usually unaffected.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Carrier status in female relatives can matter in pregnancy, as it is linked to low maternal oestriol and prolonged labour.

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How STS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where STS sits. STS and 1 gene near it on chromosome X, from 6,751,177 to 7,751,176.Chromosome XXp22.31p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q286.8 Mb7 Mb7.2 Mb7.4 Mb7.6 MbPUDP: 6,667,865–7,148,184, reverse strandPUDPSTS: 7,147,712–7,354,641, forward strandSTSDiagram of STS: 11 exons on the forward strand of chromosome XExon 5: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 7,147,712–7,148,083, 372 basesExon 2: 7,190,880–7,191,008, 129 basesExon 3: 7,253,196–7,253,336, 141 basesExon 4: 7,257,242–7,257,363, 122 basesExon 5: 7,257,466–7,257,588, 123 basesExon 6: 7,259,349–7,259,772, 424 basesExon 7: 7,275,951–7,276,087, 137 basesExon 8: 7,305,046–7,305,183, 138 basesExon 9: 7,325,339–7,325,498, 160 basesExon 10: 7,333,986–7,334,107, 122 basesExon 11: 7,349,888–7,354,641, 4,754 bases1510115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.6 kb of the gene's 206.9 kb; 1,737 of those bases code for the protein.

How a genome test reads STS

7

positions in STS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 206.9 kb of STS, introns included, not only the 6.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). STS gene: steroid sulfatase. Retrieved 16 October 2026, from https://dantelabs.com/genes/sts

Vancouver

Dante Labs. STS gene: steroid sulfatase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/sts

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test