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Gene

CDK4

cyclin dependent kinase 4

Summary

Cytogenetic location
12q14.1
Coordinates
Chromosome 12: 57,747,727–57,752,310 (GRCh38)
Exons
8 exons across 4.6 kb
Protein
303 amino acids
Inheritance
Autosomal dominant
Also known as
PSK-J3
MANE Select transcript
ENST00000257904.11NM_000075.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Melanoma

    • Susceptibility to familial cutaneous melanomaAutosomal dominant

      Inherited melanoma susceptibility caused by variants in genes such as CDKN2A, CDK4, MITF and POT1.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Regular full skin examinations, sun protection and, for CDKN2A carriers, consideration of pancreatic surveillance.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How CDK4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where CDK4 sits. CDK4 and 30 genes near it on chromosome 12, from 57,250,019 to 58,250,018.Chromosome 1212q14.1p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3357.4 Mb57.6 Mb57.8 Mb58 Mb58.2 MbSTAC3: 57,243,453–57,251,195, reverse strandSTAC3: 57,249,609–57,296,484, reverse strandR3HDM2: 57,253,762–57,431,051, reverse strandR3HDM2INHBC: 57,434,700–57,452,067, forward strandINHBCINHBE: 57,452,323–57,459,280, forward strandINHBEGLI1: 57,459,783–57,472,268, forward strandGLI1ARHGAP9: 57,472,260–57,488,831, reverse strandMARS1: 57,475,445–57,517,702, forward strandDDIT3: 57,516,584–57,523,630, reverse strandDDIT3: 57,517,712–57,520,480, reverse strandMBD6: 57,520,710–57,530,614, forward strandMBD6DCTN2: 57,529,567–57,547,256, reverse strandDCTN2KIF5A: 57,546,026–57,586,633, forward strandPIP4K2C: 57,591,161–57,603,418, forward strandDTX3: 57,604,484–57,609,804, forward strandDTX3ARHGEF25: 57,610,111–57,617,245, forward strandARHGEF25: 57,615,280–57,626,125, forward strandB4GALNT1: 57,623,409–57,633,242, reverse strandB4GALNT1OS9: 57,693,841–57,728,342, forward strandAGAP2: 57,723,761–57,742,209, reverse strandTSPAN31: 57,738,013–57,751,383, forward strandTSPAN31CDK4: 57,747,727–57,752,310, reverse strandCDK4MARCHF9: 57,754,940–57,760,411, forward strandMARCHF9CYP27B1: 57,762,334–57,768,986, reverse strandCYP27B1METTL1: 57,768,471–57,772,131, reverse strandEEF1AKMT3: 57,771,492–57,782,544, forward strand: 57,772,660–57,797,554, forward strandTSFM: 57,782,731–57,828,655, forward strandAVIL: 57,797,376–57,818,734, reverse strandCTDSP2: 57,819,925–57,846,976, reverse strandCTDSP2ATP23: 57,906,039–57,959,148, forward strandATP23Diagram of CDK4: 8 exons on the reverse strand of chromosome 12Exon 5: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 8: 57,747,727–57,748,617, 891 basesExon 7: 57,749,182–57,749,317, 136 basesExon 6: 57,749,454–57,749,504, 51 basesExon 5: 57,750,656–57,750,765, 110 basesExon 4: 57,750,923–57,751,090, 168 basesExon 3: 57,751,207–57,751,342, 136 basesExon 2: 57,751,500–57,751,736, 237 basesExon 1: 57,752,175–57,752,310, 136 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 4.6 kb; 912 of those bases code for the protein.

How a genome test reads CDK4

4

positions in CDK4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.6 kb of CDK4, introns included, not only the 1.9 kb of exons.

Genes linked to the same conditions

Traits linked to CDK4

The Human Phenotype Ontology lists these as features of the rare conditions CDK4 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CDK4 gene: cyclin dependent kinase 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/cdk4

Vancouver

Dante Labs. CDK4 gene: cyclin dependent kinase 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cdk4

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