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Gene

WNT10A

Wnt family member 10A

Summary

Cytogenetic location
2q35
Coordinates
Chromosome 2: 218,880,852–218,893,928 (GRCh38)
Exons
4 exons across 13.1 kb
Protein
417 amino acids
MANE Select transcript
ENST00000258411.8NM_025216.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Ectodermal Dysplasias

    • WNT10A-related ectodermal dysplasia

      A WNT10A disorder ranging from isolated missing teeth to odonto-onycho-dermal dysplasia with nail and skin changes.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Early dental assessment helps plan treatment for missing teeth.

  • Hereditary Palmoplantar Keratodermas and Pachyonychia Congenita

    • Hereditary palmoplantar keratoderma

      Inherited thickening of the palms and soles, including pachyonychia congenita, mal de Meleda, Nagashima-type and Bothnian keratodermas, keratitis-ichthyosis-deafness syndrome, and the CTSC-related Papillon-Lefèvre and Haim-Munk syndromes.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis guides foot care and pain management; for CTSC-related forms early dental treatment protects the teeth, and GJB2-related forms warrant a hearing check.

  • Hypodontia and Anodontia

    • Tooth Agenesis (Hypodontia)
      • 1 GenCC submitter rates it definitive or strong

How WNT10A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where WNT10A sits. WNT10A and 37 genes near it on chromosome 2, from 218,387,390 to 219,387,389.Chromosome 22q35p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3218.4 Mb218.6 Mb218.8 Mb219 Mb219.2 MbSLC11A1: 218,382,006–218,396,906, forward strandSLC11A1CTDSP1: 218,397,136–218,405,942, forward strandCTDSP1VIL1: 218,419,083–218,453,295, forward strandVIL1USP37: 218,450,251–218,568,768, reverse strandUSP37CNOT9: 218,568,575–218,597,080, forward strandCNOT9PLCD4: 218,607,855–218,637,186, forward strandPLCD4ZNF142: 218,633,329–218,659,655, reverse strandZNF142BCS1L: 218,658,764–218,668,759, forward strandBCS1LRNF25: 218,662,081–218,672,009, reverse strandRNF25STK36: 218,672,027–218,702,717, forward strandSTK36TTLL4: 218,710,773–218,759,724, forward strandTTLL4CYP27A1: 218,781,688–218,825,335, forward strandCYP27A1PRKAG3: 218,819,050–218,832,086, reverse strandPRKAG3WNT6: 218,859,795–218,874,233, forward strandWNT6WNT10A: 218,880,852–218,893,928, forward strandWNT10ACDK5R2: 218,959,666–218,962,155, forward strandCDK5R2FEV: 218,981,087–218,985,566, reverse strandFEVCRYBA2: 218,990,189–218,994,270, reverse strandCRYBA2CFAP65: 219,002,846–219,041,527, reverse strandCFAP65IHH: 219,054,424–219,061,064, reverse strandIHHNHEJ1: 219,069,355–219,160,869, reverse strandNHEJ1: 219,075,329–219,170,827, reverse strandSLC23A3: 219,161,465–219,170,095, reverse strandSLC23A3CNPPD1: 219,170,704–219,182,664, reverse strandCNPPD1RETREG2: 219,176,225–219,185,917, forward strandZFAND2B: 219,195,237–219,209,651, forward strandABCB6: 219,209,765–219,219,012, reverse strandABCB6: 219,209,772–219,222,738, reverse strandATG9A: 219,219,380–219,230,383, reverse strandANKZF1: 219,229,769–219,236,679, forward strandGLB1L: 219,236,598–219,245,478, reverse strandGLB1LSTK16: 219,245,212–219,250,339, forward strandTUBA4A: 219,249,710–219,277,902, reverse strandTUBA4B: 219,253,243–219,272,197, forward strandDNAJB2: 219,279,308–219,286,900, forward strandDNAJB2PTPRN: 219,289,623–219,309,648, reverse strandPTPRNRESP18: 219,327,407–219,335,552, reverse strandRESP18DNPEP: 219,360,090–219,400,022, reverse strandDNPEPDiagram of WNT10A: 4 exons on the forward strand of chromosome 2Exon 1: 11 known disease-causing sitesExon 2: 16 known disease-causing sitesExon 3: 33 known disease-causing sitesExon 4: 44 known disease-causing sitesExon 1: 218,880,852–218,881,108, 257 basesExon 2: 218,882,161–218,882,423, 263 basesExon 3: 218,889,984–218,890,363, 380 basesExon 4: 218,892,774–218,893,928, 1,155 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 13.1 kb; 1,254 of those bases code for the protein.

How a genome test reads WNT10A

107

positions in WNT10A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.1 kb of WNT10A, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WNT10A gene: Wnt family member 10A. Retrieved 16 October 2026, from https://dantelabs.com/genes/wnt10a

Vancouver

Dante Labs. WNT10A gene: Wnt family member 10A [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wnt10a

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