Skip to content
Use your HSA or FSA funds

Gene

PROKR2

prokineticin receptor 2

Summary

Cytogenetic location
20p12.3
Coordinates
Chromosome 20: 5,299,218–5,316,954 (GRCh38)
Exons
3 exons across 17.7 kb
Protein
384 amino acids
Also known as
GPR73b, PKR2, GPRg2, dJ680N4.3
Previous symbols
GPR73L1, KAL3
MANE Select transcript
ENST00000678254.1NM_144773.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How PROKR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where PROKR2 sits. PROKR2 and 7 genes near it on chromosome 20, from 4,808,086 to 5,808,085.Chromosome 2020p12.3p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.335 Mb5.2 Mb5.4 Mb5.6 Mb5.8 MbRASSF2: 4,780,019–4,823,870, reverse strandRASSF2SLC23A2: 4,851,729–5,010,313, reverse strandSLC23A2TMEM230: 5,068,232–5,113,452, reverse strandTMEM230PCNA: 5,114,953–5,127,630, reverse strandPCNACDS2: 5,126,879–5,197,887, forward strandCDS2PROKR2: 5,299,218–5,316,954, reverse strandPROKR2GPCPD1: 5,544,404–5,611,058, reverse strandGPCPD1SHLD1: 5,750,334–5,865,795, forward strandSHLD1Diagram of PROKR2: 3 exons on the reverse strand of chromosome 20Exon 3: 8 known disease-causing sitesExon 2: 5 known disease-causing sitesExon 3: 5,299,218–5,302,736, 3,519 basesExon 2: 5,313,912–5,314,377, 466 basesExon 1: 5,316,494–5,316,954, 461 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 17.7 kb; 1,155 of those bases code for the protein.

How a genome test reads PROKR2

13

positions in PROKR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 17.7 kb of PROKR2, introns included, not only the 4.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PROKR2 gene: prokineticin receptor 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/prokr2

Vancouver

Dante Labs. PROKR2 gene: prokineticin receptor 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prokr2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test