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Gene

ALG11

ALG11 alpha-1,2-mannosyltransferase

Summary

Cytogenetic location
13q14.3
Coordinates
Chromosome 13: 52,012,398–52,033,600 (GRCh38)
Exons
4 exons across 21.2 kb
Protein
492 amino acids
Also known as
KIAA0266, CDG1P
MANE Select transcript
ENST00000521508.2NM_001004127.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Congenital Disorders of Glycosylation

      • Congenital Disorders of Glycosylation (CDG)

        One of 98 genes linked to it

        A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

        • ClinGen rates the link moderate
        • 3 GenCC submitters rate it definitive or strong

    How ALG11 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 13, with a bracket where ALG11 sits. ALG11 and 12 genes near it on chromosome 13, from 51,522,999 to 52,522,998.Chromosome 1313q14.3p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3451.6 Mb51.8 Mb52 Mb52.2 Mb52.4 MbWDFY2: 51,583,879–51,767,709, forward strandWDFY2DHRS12: 51,751,930–51,804,187, reverse strandDHRS12: 51,763,951–51,845,159, reverse strandTMEM272: 51,813,347–51,845,272, reverse strandTMEM272CCDC70: 51,861,969–51,866,232, forward strandCCDC70ATP7B: 51,930,436–52,012,198, reverse strandATP7BALG11: 52,012,398–52,033,600, forward strandALG11UTP14C: 52,024,691–52,034,196, forward strandUTP14CNEK5: 52,033,611–52,129,094, reverse strandNEK5NEK3: 52,130,733–52,159,855, reverse strandNEK3THSD1: 52,360,302–52,416,373, reverse strandTHSD1VPS36: 52,411,117–52,450,688, reverse strandVPS36CKAP2: 52,455,429–52,476,640, forward strandCKAP2Diagram of ALG11: 4 exons on the forward strand of chromosome 13Exon 1: 3 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 1: 52,012,398–52,012,462, 65 basesExon 2: 52,018,913–52,019,143, 231 basesExon 3: 52,024,006–52,024,937, 932 basesExon 4: 52,028,319–52,033,600, 5,282 bases12345′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.5 kb of the gene's 21.2 kb; 1,479 of those bases code for the protein.

    How a genome test reads ALG11

    10

    positions in ALG11 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 21.2 kb of ALG11, introns included, not only the 6.5 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ALG11 gene: ALG11 alpha-1,2-mannosyltransferase. Retrieved 17 October 2026, from https://dantelabs.com/genes/alg11

    Vancouver

    Dante Labs. ALG11 gene: ALG11 alpha-1,2-mannosyltransferase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alg11

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