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Gene

CARS1

cysteinyl-tRNA synthetase 1

Summary

Cytogenetic location
11p15.4
Coordinates
Chromosome 11: 3,000,929–3,057,423 (GRCh38)
Exons
23 exons across 56.5 kb
Protein
831 amino acids
Previous symbols
CARS
MANE Select transcript
ENST00000380525.9NM_001014437.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads CARS1 yet. The test sequences your whole genome, so your data includes it all the same.

How CARS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where CARS1 sits. CARS1 and 9 genes near it on chromosome 11, from 2,529,176 to 3,529,175.Chromosome 1111p15.4p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q252.6 Mb2.8 Mb3 Mb3.2 Mb3.4 MbKCNQ1: 2,444,654–2,849,105, forward strandKCNQ1CDKN1C: 2,883,213–2,885,775, reverse strandCDKN1CSLC67A1: 2,899,718–2,925,247, forward strandSLC67A1PHLDA2: 2,928,273–2,929,593, reverse strandPHLDA2NAP1L4: 2,944,429–2,992,416, reverse strandNAP1L4CARS1: 3,000,929–3,057,423, reverse strandCARS1OSBPL5: 3,087,107–3,166,739, reverse strandOSBPL5MRGPRG: 3,217,944–3,218,813, reverse strandMRGPRGMRGPRE: 3,225,030–3,232,652, reverse strandMRGPREZNF195: 3,339,261–3,379,222, reverse strandZNF195Diagram of CARS1: 23 exons on the reverse strand of chromosome 11Exon 12: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 23: 3,000,929–3,001,248, 320 basesExon 22: 3,001,970–3,002,053, 84 basesExon 21: 3,002,541–3,002,600, 60 basesExon 20: 3,005,366–3,005,433, 68 basesExon 19: 3,006,879–3,006,959, 81 basesExon 18: 3,012,195–3,012,276, 82 basesExon 17: 3,015,781–3,015,849, 69 basesExon 16: 3,017,106–3,017,295, 190 basesExon 15: 3,017,857–3,017,954, 98 basesExon 14: 3,018,408–3,018,511, 104 basesExon 13: 3,018,620–3,018,749, 130 basesExon 12: 3,019,139–3,019,267, 129 basesExon 11: 3,020,220–3,020,332, 113 basesExon 10: 3,026,676–3,026,797, 122 basesExon 9: 3,028,996–3,029,084, 89 basesExon 8: 3,029,303–3,029,443, 141 basesExon 7: 3,038,050–3,038,199, 150 basesExon 6: 3,039,194–3,039,292, 99 basesExon 5: 3,039,835–3,039,931, 97 basesExon 4: 3,040,896–3,040,984, 89 basesExon 3: 3,042,165–3,042,256, 92 basesExon 2: 3,047,753–3,048,001, 249 basesExon 1: 3,057,343–3,057,423, 81 bases23201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 56.5 kb; 2,496 of those bases code for the protein.

Sequencing CARS1

4

positions in CARS1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 56.5 kb of CARS1, introns included, not only the 2.7 kb of exons.

Traits linked to CARS1

The Human Phenotype Ontology lists these as features of the rare conditions CARS1 can cause. Each trait's page lists the other genes linked to it.

Abnormality of the nervous system

Show 29 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CARS1 gene: cysteinyl-tRNA synthetase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/cars1

Vancouver

Dante Labs. CARS1 gene: cysteinyl-tRNA synthetase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cars1

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