Trait
Gout
Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues.
Summary
- Also called
- Gouty arthritis
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test22 genes linked to Gout
Changes in these genes cause rare conditions in which Gout is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APOA4apolipoprotein A4 | Always | In 1 condition |
| SLC17A3solute carrier family 17 member 3 | Always | In 1 condition |
| HPRT1hypoxanthine phosphoribosyltransferase 1 | Very often (80–99%) | In 2 conditions |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Very often (80–99%) | In 2 conditions |
| ADRA2Aadrenoceptor alpha 2A | Often (30–79%) | In 1 condition |
| HNF1BHNF1 homeobox B | Often (30–79%) | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Often (30–79%) | In 1 condition |
| UMODuromodulin | Often (30–79%) | In 1 condition |
| APOEapolipoprotein E | Sometimes (5–29%) | In 1 condition |
| DNAJB11DnaJ heat shock protein family (Hsp40) member B11 | Sometimes (5–29%) | In 1 condition |
| ANK1ankyrin 1 | Rarely (1–4%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| EPB42erythrocyte membrane protein band 4.2 | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Rarely (1–4%) | In 3 conditions |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Rarely (1–4%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| SPTBspectrin beta, erythrocytic | Rarely (1–4%) | In 1 condition |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Not recorded | In 1 condition |
| LRP6LDL receptor related protein 6 | Not recorded | In 1 condition |
| MUC1mucin 1, cell surface associated | Not recorded | In 1 condition |
| PFKMphosphofructokinase, muscle | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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