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Gene

CD79B

CD79b molecule

Summary

Cytogenetic location
17q23.3
Coordinates
Chromosome 17: 63,928,740–63,932,331 (GRCh38)
Exons
6 exons across 3.6 kb
Protein
229 amino acids
Also known as
B29, Ig-beta, Igbeta
Previous symbols
IGB
MANE Select transcript
ENST00000006750.8NM_000626.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Agammaglobulinaemia (XLA and Autosomal Forms)

    • Autosomal agammaglobulinaemia

      Absent or very few B cells caused by changes in genes of the B-cell receptor pathway, such as IGHM, IGLL1, CD79A, CD79B, BLNK, PIK3R1 and TCF3.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Lifelong immunoglobulin replacement, prompt treatment of infections and avoiding live vaccines prevent most serious complications.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How CD79B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 17, with a bracket where CD79B sits. CD79B and 28 genes near it on chromosome 17, from 63,430,536 to 64,430,535.Chromosome 1717q23.3p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.363.6 Mb63.8 Mb64 Mb64.2 Mb64.4 MbCYB561: 63,432,298–63,447,108, reverse strandCYB561ACE: 63,477,058–63,498,380, forward strandACE: 63,484,823–63,521,848, forward strandKCNH6: 63,523,310–63,548,987, forward strandKCNH6DCAF7: 63,550,222–63,594,286, forward strandDCAF7: 63,550,603–63,608,347, forward strandTACO1: 63,600,879–63,612,023, forward strandTACO1MAP3K3: 63,622,379–63,696,310, forward strandMAP3K3STRADA: 63,682,336–63,742,005, reverse strandSTRADALIMD2: 63,695,883–63,701,183, reverse strandLIMD2: 63,702,845–63,752,097, reverse strandCCDC47: 63,745,250–63,776,351, reverse strandCCDC47DDX42: 63,773,603–63,820,451, forward strandDDX42FTSJ3: 63,819,113–63,830,012, reverse strandFTSJ3PSMC5: 63,827,082–63,832,244, forward strandPSMC5SMARCD2: 63,832,078–63,843,065, reverse strandSMARCD2CSH2: 63,872,007–63,873,769, reverse strandCSH2GH2: 63,880,205–63,881,970, reverse strandGH2CSH1: 63,894,906–63,896,667, reverse strandCSHL1: 63,909,596–63,911,348, reverse strandCSHL1GH1: 63,917,200–63,918,839, reverse strandGH1: 63,917,203–63,931,385, reverse strandCD79B: 63,928,740–63,932,331, reverse strandCD79BSCN4A: 63,938,554–63,972,918, reverse strandPRR29: 63,998,344–64,004,305, forward strandPRR29ICAM2: 64,002,594–64,020,640, reverse strandICAM2ERN1: 64,039,080–64,130,819, reverse strandERN1TEX2: 64,147,227–64,263,293, reverse strandTEX2PECAM1: 64,319,415–64,431,594, reverse strandPECAM1Diagram of CD79B: 6 exons on the reverse strand of chromosome 17Exon 6: 63,928,740–63,929,324, 585 basesExon 5: 63,929,434–63,929,475, 42 basesExon 4: 63,929,770–63,929,888, 119 basesExon 3: 63,930,074–63,930,385, 312 basesExon 2: 63,931,335–63,931,385, 51 basesExon 1: 63,932,195–63,932,331, 137 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 3.6 kb; 690 of those bases code for the protein.

How a genome test reads CD79B

1

position in CD79B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.6 kb of CD79B, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CD79B gene: CD79b molecule. Retrieved 16 October 2026, from https://dantelabs.com/genes/cd79b

Vancouver

Dante Labs. CD79B gene: CD79b molecule [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cd79b

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