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Gene

THSD4

thrombospondin type 1 domain containing 4

Summary

Cytogenetic location
15q23
Coordinates
Chromosome 15: 71,115,471–71,783,383 (GRCh38)
Exons
18 exons across 667.9 kb
Protein
1,018 amino acids
Inheritance
Autosomal dominant
Also known as
FVSY9334, PRO34005, FLJ13710, ADAMTSL6
MANE Select transcript
ENST00000261862.8NM_024817.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Aortic Aneurysm

    • Familial Thoracic Aortic Aneurysm and DissectionAutosomal dominant

      Inherited widening and tearing of the thoracic aorta, caused by changes in genes such as ACTA2, MYH11, MYLK, LOX, PRKG1, MFAP5 and THSD4.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing about it supports regular aortic imaging, blood pressure control and timely preventive surgery, and screening of relatives.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How THSD4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where THSD4 sits. THSD4 and 15 genes near it on chromosome 15, from 70,447,558 to 72,451,296.Chromosome 1515q23p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.370.5 Mb71 Mb71.5 Mb72 MbUACA: 70,654,554–70,763,570, reverse strandUACALARP6: 70,829,130–70,854,783, reverse strandLARP6LRRC49: 70,853,239–71,071,702, forward strandLRRC49THAP10: 70,881,330–70,892,570, reverse strandTHAP10THSD4: 71,115,471–71,783,383, forward strandTHSD4NR2E3: 71,792,638–71,818,259, forward strandNR2E3MYO9A: 71,822,291–72,118,577, reverse strandMYO9ASENP8: 72,114,258–72,143,692, forward strandSENP8GRAMD2A: 72,159,806–72,197,830, reverse strandGRAMD2APKM: 72,199,024–72,231,819, reverse strandPKMPARP6: 72,241,176–72,272,999, reverse strandPARP6: 72,266,746–72,319,946, reverse strandCELF6: 72,284,727–72,320,622, reverse strandCELF6: 72,284,727–72,375,981, reverse strandHEXA: 72,340,919–72,376,420, reverse strandHEXATMEM202: 72,398,302–72,408,367, forward strandTMEM202Diagram of THSD4: 18 exons on the forward strand of chromosome 15Exon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 1: 71,115,471–71,115,698, 228 basesExon 2: 71,141,449–71,141,556, 108 basesExon 3: 71,154,863–71,154,932, 70 basesExon 4: 71,215,035–71,215,399, 365 basesExon 5: 71,242,649–71,243,096, 448 basesExon 6: 71,256,613–71,256,715, 103 basesExon 7: 71,411,687–71,411,823, 137 basesExon 8: 71,660,530–71,660,734, 205 basesExon 9: 71,728,549–71,728,724, 176 basesExon 10: 71,731,121–71,731,217, 97 basesExon 11: 71,737,732–71,738,007, 276 basesExon 12: 71,745,106–71,745,235, 130 basesExon 13: 71,746,838–71,747,042, 205 basesExon 14: 71,748,421–71,748,594, 174 basesExon 15: 71,757,902–71,758,075, 174 basesExon 16: 71,765,020–71,765,199, 180 basesExon 17: 71,771,064–71,771,208, 145 basesExon 18: 71,777,232–71,783,383, 6,152 bases151015185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.4 kb of the gene's 667.9 kb; 3,057 of those bases code for the protein.

How a genome test reads THSD4

4

positions in THSD4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 667.9 kb of THSD4, introns included, not only the 9.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). THSD4 gene: thrombospondin type 1 domain containing 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/thsd4

Vancouver

Dante Labs. THSD4 gene: thrombospondin type 1 domain containing 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/thsd4

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