Skip to content
Use your HSA or FSA funds

Gene

ELF4

E74 like ETS transcription factor 4

Summary

Cytogenetic location
Xq26.1
Coordinates
Chromosome X: 130,063,955–130,110,497 (GRCh38)
Exons
9 exons across 46.5 kb
Protein
663 amino acids
Inheritance
X-linked recessive
Also known as
MEF, ELFR
MANE Select transcript
ENST00000308167.10NM_001421.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • ELF4 deficiency (Behcet-like autoinflammatory syndrome 2)X-linked recessive

      Mouth ulcers, fevers and gut inflammation in males, caused by variants in ELF4.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How ELF4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome X, with a bracket where ELF4 sits. ELF4 and 13 genes near it on chromosome X, from 129,587,226 to 130,587,225.Chromosome XXq26.1p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28129.6 Mb129.8 Mb130 Mb130.2 Mb130.4 MbOCRL: 129,539,849–129,592,772, forward strandOCRLAPLN: 129,645,259–129,654,965, reverse strandAPLNXPNPEP2: 129,738,949–129,770,164, forward strandXPNPEP2SASH3: 129,779,901–129,795,201, forward strandSASH3ZDHHC9: 129,797,030–129,844,215, reverse strandZDHHC9UTP14A: 129,906,114–129,929,957, forward strandUTP14ABCORL1: 129,981,107–130,058,071, forward strandBCORL1ELF4: 130,063,955–130,110,497, reverse strandELF4AIFM1: 130,124,666–130,165,884, reverse strandAIFM1RAB33A: 130,171,720–130,184,874, forward strandRAB33AZNF280C: 130,202,699–130,268,923, reverse strandZNF280CSLC25A14: 130,339,886–130,373,453, forward strandSLC25A14GPR119: 130,379,449–130,385,674, reverse strandGPR119RBMX2: 130,401,922–130,462,404, forward strandRBMX2Diagram of ELF4: 9 exons on the reverse strand of chromosome XExon 9: 130,063,955–130,067,525, 3,571 basesExon 8: 130,069,300–130,069,677, 378 basesExon 7: 130,071,040–130,071,232, 193 basesExon 6: 130,071,336–130,071,419, 84 basesExon 5: 130,072,226–130,072,417, 192 basesExon 4: 130,074,049–130,074,141, 93 basesExon 3: 130,074,581–130,074,752, 172 basesExon 2: 130,081,256–130,081,539, 284 basesExon 1: 130,110,325–130,110,497, 173 bases9864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 46.5 kb; 1,992 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ELF4 gene: E74 like ETS transcription factor 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/elf4

Vancouver

Dante Labs. ELF4 gene: E74 like ETS transcription factor 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/elf4

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test