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Gene

ABCG2

ATP binding cassette subfamily G member 2 (JR blood group)

Summary

Cytogenetic location
4q22.1
Coordinates
Chromosome 4: 88,090,269–88,158,639 (GRCh38)
Exons
16 exons across 68.4 kb
Protein
655 amino acids
Also known as
EST157481, MXR, BCRP, ABCP, CD338
MANE Select transcript
ENST00000237612.8NM_004827.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

ABCG2 and medicines

  • Rosuvastatin exposure

    Pharmacogenomics

    ABCG2 pumps rosuvastatin out of cells and into bile. The Q141K variant weakens that transport, raising blood levels of the drug — and it also tracks with a weaker response to allopurinol.

    • Relevant mainly if you are on a high rosuvastatin dose, or if allopurinol is not controlling gout as expected.

    Alleles the report reads

    • rs2231142 variant (T)Decreased function
    • rs2231142 reference (G)Normal function

    Results CPIC describes

    • Normal Function
    • Decreased Function
    • Poor Function
    MedicineCPIC levelGuideline
    rosuvastatinASLCO1B1, ABCG2, CYP2C9, and Statins

How ABCG2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where ABCG2 sits. ABCG2 and 12 genes near it on chromosome 4, from 87,624,454 to 88,624,453.Chromosome 44q22.1p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.287.8 Mb88 Mb88.2 Mb88.4 Mb88.6 MbDMP1: 87,650,278–87,664,361, forward strandDMP1IBSP: 87,799,546–87,813,329, forward strandIBSPMEPE: 87,821,398–87,846,814, forward strandMEPESPP1: 87,975,667–87,983,532, forward strandSPP1PKD2: 88,007,586–88,077,777, forward strandPKD2ABCG2: 88,090,269–88,158,639, reverse strandABCG2PPM1K: 88,257,620–88,284,769, reverse strandPPM1KHERC6: 88,378,734–88,443,098, forward strandHERC6HERC5: 88,457,086–88,506,188, forward strandHERC5PIGY: 88,520,986–88,523,776, reverse strandPIGYPYURF: 88,520,986–88,523,794, reverse strandPYURFHERC3: 88,523,810–88,708,450, forward strandHERC3HERC3: 88,592,372–88,708,540, forward strandHERC3Diagram of ABCG2: 16 exons on the reverse strand of chromosome 4Exon 16: 88,090,269–88,092,381, 2,113 basesExon 15: 88,094,577–88,094,659, 83 basesExon 14: 88,095,520–88,095,609, 90 basesExon 13: 88,097,453–88,097,607, 155 basesExon 12: 88,099,324–88,099,448, 125 basesExon 11: 88,101,230–88,101,319, 90 basesExon 10: 88,107,184–88,107,266, 83 basesExon 9: 88,113,303–88,113,553, 251 basesExon 8: 88,114,957–88,115,058, 102 basesExon 7: 88,118,109–88,118,260, 152 basesExon 6: 88,121,635–88,121,792, 158 basesExon 5: 88,131,061–88,131,213, 153 basesExon 4: 88,131,803–88,131,917, 115 basesExon 3: 88,132,576–88,132,635, 60 basesExon 2: 88,139,793–88,140,014, 222 basesExon 1: 88,158,386–88,158,639, 254 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 68.4 kb; 1,968 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • CPIC and PharmGKB: the alleles, results and medicines.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). ABCG2 gene: ATP binding cassette subfamily G member 2 (JR blood group). Retrieved 17 October 2026, from https://dantelabs.com/genes/abcg2

Vancouver

Dante Labs. ABCG2 gene: ATP binding cassette subfamily G member 2 (JR blood group) [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/abcg2

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