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Gene

SERPINF2

serpin family F member 2

Summary

Cytogenetic location
17p13.3
Coordinates
Chromosome 17: 1,742,871–1,755,265 (GRCh38)
Exons
10 exons across 12.4 kb
Protein
491 amino acids
Inheritance
Autosomal recessive
Also known as
API, ALPHA-2-PI, A2AP, AAP, alpha2AP
Previous symbols
PLI
MANE Select transcript
ENST00000453066.6NM_000934.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Fibrinolytic Disorders

    • Alpha-2-Plasmin Inhibitor DeficiencyAutosomal recessive

      Caused by changes in both copies of SERPINF2, clots break down too early, leading to bleeding that can be severe, including bleeding into joints.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Tranexamic acid, a medicine that slows clot breakdown, is effective in preventing and treating bleeding.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SERPINF2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 17, with a bracket where SERPINF2 sits. SERPINF2 and 21 genes near it on chromosome 17, from 1,249,068 to 2,249,067.Chromosome 1717p13.3p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.31.4 Mb1.6 Mb1.8 Mb2 Mb2.2 MbBHLHA9: 1,270,444–1,271,815, forward strandBHLHA9TRARG1: 1,279,554–1,300,978, forward strandTRARG1YWHAE: 1,344,275–1,400,326, reverse strandYWHAECRK: 1,420,689–1,463,162, reverse strandCRKMYO1C: 1,464,186–1,492,707, reverse strandMYO1CINPP5K: 1,494,571–1,516,759, reverse strandINPP5KPITPNA: 1,517,718–1,562,861, reverse strandPITPNASLC43A2: 1,569,268–1,630,103, reverse strandSLC43A2SCARF1: 1,633,848–1,646,122, reverse strandSCARF1RILP: 1,646,138–1,650,083, reverse strandRILPPRPF8: 1,650,624–1,684,909, reverse strandPRPF8TLCD2: 1,688,598–1,710,639, reverse strandTLCD2WDR81: 1,716,523–1,738,599, forward strandWDR81SERPINF2: 1,742,871–1,755,265, forward strandSERPINF2SERPINF1: 1,761,958–1,777,627, forward strandSERPINF1SMYD4: 1,779,485–1,830,634, reverse strandSMYD4RPA1: 1,829,702–1,900,082, forward strandRPA1RTN4RL1: 1,934,677–2,025,355, reverse strandRTN4RL1DPH1: 2,030,136–2,043,898, forward strandDPH1OVCA2: 2,042,022–2,043,898, forward strandOVCA2HIC1: 2,054,154–2,063,241, forward strandHIC1SMG6: 2,059,839–2,303,934, reverse strandSMG6Diagram of SERPINF2: 10 exons on the forward strand of chromosome 17Exon 1: 1,742,871–1,742,908, 38 basesExon 2: 1,744,992–1,745,058, 67 basesExon 3: 1,745,175–1,745,213, 39 basesExon 4: 1,745,333–1,745,395, 63 basesExon 5: 1,745,708–1,745,909, 202 basesExon 6: 1,747,019–1,747,162, 144 basesExon 7: 1,747,309–1,747,512, 204 basesExon 8: 1,748,598–1,748,740, 143 basesExon 9: 1,752,586–1,752,790, 205 basesExon 10: 1,754,122–1,755,265, 1,144 bases12468105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 12.4 kb; 1,476 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SERPINF2 gene: serpin family F member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/serpinf2

Vancouver

Dante Labs. SERPINF2 gene: serpin family F member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/serpinf2

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