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Gene

SF3B1

splicing factor 3b subunit 1

Summary

Cytogenetic location
2q33.1
Coordinates
Chromosome 2: 197,389,784–197,435,028 (GRCh38)
Exons
25 exons across 45.2 kb
Protein
1,304 amino acids
Also known as
SAP155, SF3b155, PRPF10, Prp10, Hsh155
MANE Select transcript
ENST00000335508.11NM_012433.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SF3B1 yet. The test sequences your whole genome, so your data includes it all the same.

How SF3B1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where SF3B1 sits. SF3B1 and 11 genes near it on chromosome 2, from 196,912,406 to 197,912,405.Chromosome 22q33.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3197 Mb197.2 Mb197.4 Mb197.6 Mb197.8 MbPGAP1: 196,833,004–196,927,796, reverse strandPGAP1ANKRD44: 196,967,017–197,311,173, reverse strandANKRD44SF3B1: 197,389,784–197,435,028, reverse strandSF3B1COQ10B: 197,453,438–197,475,488, forward strandCOQ10BHSPD1: 197,485,928–197,516,737, reverse strandHSPD1HSPE1: 197,500,110–197,513,408, forward strandHSPE1HSPE1-MOB4: 197,500,413–197,550,726, forward strandHSPE1-MOB4MOB4: 197,515,571–197,553,699, forward strandMOB4RFTN2: 197,568,224–197,676,168, reverse strandRFTN2MARS2: 197,705,369–197,708,395, forward strandMARS2BOLL: 197,726,879–197,786,762, reverse strandBOLLPLCL1: 197,804,541–198,572,581, forward strandPLCL1Diagram of SF3B1: 25 exons on the reverse strand of chromosome 2Exon 14: 2 known disease-causing sitesExon 25: 197,389,784–197,392,461, 2,678 basesExon 24: 197,392,972–197,393,188, 217 basesExon 23: 197,396,056–197,396,328, 273 basesExon 22: 197,397,985–197,398,116, 132 basesExon 21: 197,398,461–197,398,581, 121 basesExon 20: 197,400,055–197,400,166, 112 basesExon 19: 197,400,252–197,400,434, 183 basesExon 18: 197,400,715–197,400,936, 222 basesExon 17: 197,401,400–197,401,525, 126 basesExon 16: 197,401,742–197,401,888, 147 basesExon 15: 197,401,985–197,402,130, 146 basesExon 14: 197,402,556–197,402,826, 271 basesExon 13: 197,402,949–197,403,035, 87 basesExon 12: 197,403,585–197,403,764, 180 basesExon 11: 197,405,076–197,405,177, 102 basesExon 10: 197,405,275–197,405,472, 198 basesExon 9: 197,407,998–197,408,119, 122 basesExon 8: 197,408,369–197,408,581, 213 basesExon 7: 197,409,770–197,410,007, 238 basesExon 6: 197,416,741–197,416,911, 171 basesExon 5: 197,418,509–197,418,588, 80 basesExon 4: 197,420,428–197,420,542, 115 basesExon 3: 197,421,029–197,421,133, 105 basesExon 2: 197,423,808–197,423,974, 167 basesExon 1: 197,434,972–197,435,028, 57 bases25201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.5 kb of the gene's 45.2 kb; 3,915 of those bases code for the protein.

How a genome test reads SF3B1

2

positions in SF3B1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 45.2 kb of SF3B1, introns included, not only the 6.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SF3B1 gene: splicing factor 3b subunit 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/sf3b1

Vancouver

Dante Labs. SF3B1 gene: splicing factor 3b subunit 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sf3b1

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