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Gene

F2

coagulation factor II, thrombin

Summary

Cytogenetic location
11p11.2
Coordinates
Chromosome 11: 46,719,213–46,739,506 (GRCh38)
Exons
14 exons across 20.3 kb
Protein
622 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000311907.10NM_000506.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Rare Inherited Coagulation Factor Deficiencies

    • Congenital Vitamin K-Dependent Coagulation Factor DeficienciesAutosomal recessive

      Inherited deficiencies of prothrombin (factor II), factor VII or factor X, or of all vitamin K-dependent factors together (caused by changes in GGCX or VKORC1), which can cause nosebleeds, easy bruising and bleeding after injury, surgery or childbirth.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing in advance allows factor replacement to be planned around surgery and childbirth; the combined form often responds to vitamin K.

  • Thrombophilia

    • Inherited Thrombophilia
      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Anticoagulation (duration by genotype); avoid estrogen-containing contraceptives; LMWH for pregnancy prophylaxis; extended post-surgical anticoagulation; lifelong anticoagulation for compound/high-risk genotypes

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How F2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where F2 sits. F2 and 15 genes near it on chromosome 11, from 46,229,360 to 47,229,359.Chromosome 1111p11.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2546.4 Mb46.6 Mb46.8 Mb47 Mb47.2 MbCREB3L1: 46,277,636–46,321,422, forward strandCREB3L1DGKZ: 46,332,665–46,380,555, forward strandDGKZMDK: 46,380,748–46,383,837, forward strandMDKCHRM4: 46,383,589–46,391,990, reverse strandCHRM4AMBRA1: 46,396,414–46,594,242, reverse strandAMBRA1HARBI1: 46,601,280–46,617,909, reverse strandHARBI1ATG13: 46,617,251–46,674,818, forward strandATG13ARHGAP1: 46,677,075–46,700,977, reverse strandARHGAP1ZNF408: 46,701,011–46,705,913, forward strandZNF408F2: 46,719,213–46,739,506, forward strandF2CKAP5: 46,742,768–46,846,308, reverse strandCKAP5LRP4: 46,856,717–46,918,642, reverse strandLRP4CSTPP1: 46,936,689–47,165,535, forward strandCSTPP1ARFGAP2: 47,135,667–47,177,474, reverse strandARFGAP2PACSIN3: 47,177,511–47,187,487, reverse strandPACSIN3DDB2: 47,214,435–47,240,555, forward strandDDB2Diagram of F2: 14 exons on the forward strand of chromosome 11Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 4 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 3 known disease-causing sitesExon 13: 1 known disease-causing siteExon 14: 7 known disease-causing sitesExon 1: 46,719,213–46,719,314, 102 basesExon 2: 46,719,702–46,719,862, 161 basesExon 3: 46,720,523–46,720,547, 25 basesExon 4: 46,720,790–46,720,840, 51 basesExon 5: 46,723,180–46,723,285, 106 basesExon 6: 46,723,382–46,723,518, 137 basesExon 7: 46,725,859–46,726,173, 315 basesExon 8: 46,726,498–46,726,626, 129 basesExon 9: 46,726,711–46,726,837, 127 basesExon 10: 46,727,996–46,728,163, 168 basesExon 11: 46,728,664–46,728,837, 174 basesExon 12: 46,729,380–46,729,561, 182 basesExon 13: 46,739,048–46,739,118, 71 basesExon 14: 46,739,265–46,739,506, 242 bases124681012145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 20.3 kb; 1,869 of those bases code for the protein.

How a genome test reads F2

30

positions in F2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 20.3 kb of F2, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). F2 gene: coagulation factor II, thrombin. Retrieved 16 October 2026, from https://dantelabs.com/genes/f2

Vancouver

Dante Labs. F2 gene: coagulation factor II, thrombin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/f2

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