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Gene

TMTC3

transmembrane O-mannosyltransferase targeting cadherins 3

Summary

Cytogenetic location
12q21.32
Coordinates
Chromosome 12: 88,142,307–88,199,887 (GRCh38)
Exons
14 exons across 57.6 kb
Protein
914 amino acids
Also known as
FLJ90492, SMILE
MANE Select transcript
ENST00000266712.11NM_181783.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TMTC3 yet. The test sequences your whole genome, so your data includes it all the same.

How TMTC3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where TMTC3 sits. TMTC3 and 4 genes near it on chromosome 12, from 87,671,097 to 88,671,096.Chromosome 1212q21.32p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3387.8 Mb88 Mb88.2 Mb88.4 Mb88.6 MbZC3H11D: 87,980,035–88,034,037, reverse strandZC3H11DRLIG1: 88,033,846–88,050,160, forward strandRLIG1CEP290: 88,049,016–88,142,099, reverse strandCEP290TMTC3: 88,142,307–88,199,887, forward strandTMTC3KITLG: 88,492,789–88,580,851, reverse strandKITLGDiagram of TMTC3: 14 exons on the forward strand of chromosome 12Exon 6: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 14: 2 known disease-causing sitesExon 1: 88,142,307–88,142,487, 181 basesExon 2: 88,148,288–88,148,504, 217 basesExon 3: 88,153,291–88,153,509, 219 basesExon 4: 88,154,288–88,154,387, 100 basesExon 5: 88,160,114–88,160,229, 116 basesExon 6: 88,160,679–88,160,851, 173 basesExon 7: 88,166,330–88,166,582, 253 basesExon 8: 88,172,597–88,172,745, 149 basesExon 9: 88,174,607–88,174,727, 121 basesExon 10: 88,176,208–88,176,319, 112 basesExon 11: 88,188,843–88,188,946, 104 basesExon 12: 88,190,453–88,190,622, 170 basesExon 13: 88,192,604–88,192,830, 227 basesExon 14: 88,194,838–88,199,887, 5,050 bases124681012145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 57.6 kb; 2,745 of those bases code for the protein.

How a genome test reads TMTC3

11

positions in TMTC3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 57.6 kb of TMTC3, introns included, not only the 7.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TMTC3 gene: transmembrane O-mannosyltransferase targeting cadherins 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/tmtc3

Vancouver

Dante Labs. TMTC3 gene: transmembrane O-mannosyltransferase targeting cadherins 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tmtc3

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