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Gene

SERPINE1

serpin family E member 1

Summary

Cytogenetic location
7q22.1
Coordinates
Chromosome 7: 101,127,104–101,139,247 (GRCh38)
Exons
9 exons across 12.1 kb
Protein
402 amino acids
Inheritance
Autosomal recessive
Also known as
PAI
Previous symbols
PLANH1, PAI1
MANE Select transcript
ENST00000223095.5NM_000602.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Fibrinolytic Disorders

    • Plasminogen Activator Inhibitor-1 (PAI-1) DeficiencyAutosomal recessive

      Caused by changes in both copies of SERPINE1, clots break down too early, leading to bleeding after injury, surgery or childbirth and heavy periods.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Tranexamic acid, a medicine that slows clot breakdown, is effective in preventing and treating bleeding.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SERPINE1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 7, with a bracket where SERPINE1 sits. SERPINE1 and 28 genes near it on chromosome 7, from 100,633,176 to 101,633,175.Chromosome 77q22.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3100.8 Mb101 Mb101.2 Mb101.4 Mb101.6 MbTFR2: 100,620,416–100,642,779, reverse strandTFR2ACTL6B: 100,643,097–100,656,458, reverse strandACTL6BGNB2: 100,673,477–100,679,174, forward strandGNB2GIGYF1: 100,679,505–100,694,481, reverse strandGIGYF1POP7: 100,695,902–100,708,628, forward strandPOP7EPO: 100,720,465–100,723,700, forward strandEPOZAN: 100,733,595–100,797,797, forward strandZANEPHB4: 100,802,563–100,827,584, reverse strandEPHB4SLC12A9: 100,826,820–100,867,017, forward strandTRIP6: 100,867,126–100,873,524, forward strandTRIP6SRRT: 100,875,065–100,888,664, forward strandSRRTUFSP1: 100,888,721–100,889,715, reverse strandUFSP1ACHE: 100,889,993–100,897,022, reverse strandACHEMUC3A: 100,949,414–100,968,348, forward strandMUC3AMUC12: 100,969,431–101,018,940, forward strandMUC12MUC17: 101,020,072–101,058,859, forward strandMUC17TRIM56: 101,085,234–101,097,967, forward strandTRIM56SERPINE1: 101,127,104–101,139,247, forward strandSERPINE1AP1S1: 101,154,352–101,161,596, forward strandAP1S1VGF: 101,162,509–101,167,245, reverse strandVGFNAT16: 101,170,496–101,180,301, reverse strandNAT16MOGAT3: 101,195,007–101,201,088, reverse strandPLOD3: 101,205,977–101,219,968, reverse strandPLOD3ZNHIT1: 101,218,117–101,224,195, forward strandZNHIT1CLDN15: 101,232,092–101,238,820, reverse strandCLDN15FIS1: 101,239,458–101,252,321, reverse strandFIS1IFT22: 101,310,914–101,321,831, reverse strandIFT22COL26A1: 101,362,407–101,559,029, forward strandCOL26A1MYL10: 101,613,330–101,629,296, reverse strandMYL10Diagram of SERPINE1: 9 exons on the forward strand of chromosome 7Exon 1: 101,127,104–101,127,244, 141 basesExon 2: 101,128,393–101,128,664, 272 basesExon 3: 101,130,421–101,130,654, 234 basesExon 4: 101,131,875–101,132,069, 195 basesExon 5: 101,133,695–101,133,893, 199 basesExon 6: 101,135,494–101,135,594, 101 basesExon 7: 101,135,715–101,135,801, 87 basesExon 8: 101,137,001–101,137,084, 84 basesExon 9: 101,137,405–101,139,247, 1,843 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.2 kb of the gene's 12.1 kb; 1,209 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SERPINE1 gene: serpin family E member 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/serpine1

Vancouver

Dante Labs. SERPINE1 gene: serpin family E member 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/serpine1

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