Gene
F13B
coagulation factor XIII B chain
- HGNC 3534(opens in a new tab)
- Ensembl gene ENSG00000143278(opens in a new tab)
- NCBI Gene 2165(opens in a new tab)
Summary
- Cytogenetic location
- 1q31.3
- Coordinates
- Chromosome 1: 197,038,741–197,067,260 (GRCh38)
- Exons
- 12 exons across 28.5 kb
- Protein
- 661 amino acids
- Inheritance
- Autosomal recessive
- Also known as
- FXIIIB
- MANE Select transcript
- ENST00000367412.2NM_001994.3
- Locus type
- gene with protein product
Reference genomeGRCh38hg38
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Rare Inherited Coagulation Factor Deficiencies
- Congenital Factor XIII DeficiencyAutosomal recessive
A deficiency of the clot-stabilising factor XIII, caused by changes in F13A1 or F13B, that can cause umbilical cord bleeding in newborns, poor wound healing, miscarriage and bleeding inside the skull; routine clotting tests are normal.
- ClinGen rates the link definitive
- 3 GenCC submitters rate it definitive or strong
What knowing changes
Regular preventive factor XIII replacement greatly reduces the risk of serious bleeding.
Inheritance
- Autosomal recessive
- It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.
How F13B is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.7 kb of the gene's 28.5 kb; 1,986 of those bases code for the protein.
How a genome test reads F13B
8
positions in F13B where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 28.5 kb of F13B, introns included, not only the 2.7 kb of exons.
Traits linked to F13B
The Human Phenotype Ontology lists these as features of the rare conditions F13B can cause. Each trait's page lists the other genes linked to it.
Abnormality of blood and blood-forming tissues
- Bleeding tendency
- Factor XIII subunit B deficiency
- Reduced factor XIII activity
- Abnormal umbilical stump bleeding
- Bleeding below the skin
- Bleeding in brain
- Bleeding within a joint
- Bruising susceptibility
Show 14 more traits
- Oral cavity bleeding
- Prolonged bleeding after surgery
- Spontaneous hematomas
- Abnormally heavy bleeding during menstruation
- Bleeding gums
- Bleeding post-delivery
- Bleeding with minor or no trauma
- Bloody nose
- Delayed onset bleeding
- Ecchymosis
- Excessive bleeding after minor trauma
- Prolonged bleeding after dental extraction
- Prolonged bleeding following circumcision
- Myeloid leukemia
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). F13B gene: coagulation factor XIII B chain. Retrieved 16 October 2026, from https://dantelabs.com/genes/f13b
Dante Labs. F13B gene: coagulation factor XIII B chain [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/f13b
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