Skip to content
Use your HSA or FSA funds

Gene

THPO

thrombopoietin

Summary

Cytogenetic location
3q27.1
Coordinates
Chromosome 3: 184,371,935–184,378,207 (GRCh38)
Exons
6 exons across 6.3 kb
Protein
353 amino acids
Also known as
TPO, MPLLG
Previous symbols
MGDF
MANE Select transcript
ENST00000647395.1NM_000460.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How THPO is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where THPO sits. THPO and 25 genes near it on chromosome 3, from 183,875,071 to 184,875,070.Chromosome 33q27.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29184 Mb184.2 Mb184.4 Mb184.6 Mb184.8 Mb: 183,815,568–183,884,889, reverse strandPARL: 183,826,489–183,884,933, reverse strandPARLABCC5: 183,919,934–184,018,307, reverse strandABCC5HTR3D: 184,031,544–184,039,369, forward strandHTR3DHTR3C: 184,053,047–184,060,673, forward strandHTR3CHTR3E: 184,097,064–184,106,995, forward strandHTR3EEIF2B5: 184,134,986–184,146,127, forward strandEIF2B5DVL3: 184,155,159–184,173,616, forward strandDVL3AP2M1: 184,174,689–184,184,214, forward strandAP2M1ABCF3: 184,186,095–184,194,451, forward strandABCF3VWA5B2: 184,228,996–184,242,342, forward strandALG3: 184,242,301–184,249,571, reverse strandEEF1AKMT4: 184,249,609–184,258,759, forward strandEEF1AKMT4-ECE2: 184,249,695–184,293,031, forward strandCAMK2N2: 184,259,213–184,261,602, reverse strandCAMK2N2ECE2: 184,275,531–184,293,031, forward strandECE2PSMD2: 184,299,157–184,309,054, forward strandPSMD2EIF4G1: 184,314,490–184,335,358, forward strandEIF4G1FAM131A: 184,335,916–184,348,421, forward strandCLCN2: 184,346,185–184,363,274, reverse strandCLCN2POLR2H: 184,360,856–184,368,596, forward strandPOLR2HTHPO: 184,371,935–184,378,207, reverse strandTHPOCHRD: 184,379,381–184,390,736, forward strandCHRDEPHB3: 184,561,751–184,582,408, forward strandEPHB3MAGEF1: 184,708,749–184,712,073, reverse strandMAGEF1VPS8: 184,812,113–185,054,009, forward strandVPS8Diagram of THPO: 6 exons on the reverse strand of chromosome 3Exon 6: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 6: 184,371,935–184,373,178, 1,244 basesExon 5: 184,373,415–184,373,582, 168 basesExon 4: 184,375,515–184,375,601, 87 basesExon 3: 184,375,888–184,376,015, 128 basesExon 2: 184,376,247–184,376,404, 158 basesExon 1: 184,378,075–184,378,207, 133 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 6.3 kb; 1,062 of those bases code for the protein.

How a genome test reads THPO

5

positions in THPO where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6.3 kb of THPO, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). THPO gene: thrombopoietin. Retrieved 17 October 2026, from https://dantelabs.com/genes/thpo

Vancouver

Dante Labs. THPO gene: thrombopoietin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/thpo

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test